(Q45715391)

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Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

scientific article published on 9 June 2014

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Europe PubMed Central

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15 December 2017

Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs (English)

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Europe PubMed Central

PubMed publication ID

15 December 2017

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848561%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Yoshihisa Fujita

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848561%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Michiyuki Matsuda

3

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4 June 2020

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Naoki Komatsu

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4 June 2020

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9 June 2014

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15 December 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848561%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

281

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4 June 2020

14

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4 June 2020

3177-3192

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4 June 2020

Mammalian MAP kinase signalling cascades

1 reference

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Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

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Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization

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Network quantification of EGFR signaling unveils potential for targeted combination therapy.

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Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration

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Development of an optimized backbone of FRET biosensors for kinases and GTPases

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Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK.

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Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation

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21 January 2018

Cooperative activation of PI3K by Ras and Rho family small GTPases

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BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

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Defining network topologies that can achieve biochemical adaptation.

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

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Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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BRAF mutation predicts sensitivity to MEK inhibition

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21 January 2018

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

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21 January 2018

Regulation of Raf-1 by direct feedback phosphorylation.

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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Membrane-dependent signal integration by the Ras activator Son of sevenless

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Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

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Identifiers

10.1111/FEBS.12852

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848561%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24848561%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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