(Q45799135)

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Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase

scientific article published on February 10, 1983

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11 September 2019

Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase (English)

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11 September 2019

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B. A. Larder

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D. Derse

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Y. C. Cheng

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G. Darby

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1 February 1983

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11 September 2019

10 February 1983

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National Center for Biotechnology Information

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19 September 2023

full work available at URL

https://doi.org/10.1016/s0021-9258(18)33092-8

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http://intl.jbc.org/cgi/content/abstract/258/3/2027

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Journal of Biological Chemistry

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11 September 2019

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11 September 2019

2027-2033

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11 September 2019

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11 September 2019

Archives internationales de physiologie et de biochimie

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87

353

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De Clercq

publication date

1979

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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

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Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

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On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine

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Molecular Pharmacology

7

20

415

author name string

Ruth

publication date

1981

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A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK)

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Molecular Pharmacology

10

20

230

author name string

Cheng

publication date

1981

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Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

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Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci

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Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

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In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine)

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MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY

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Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.

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The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

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Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

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Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion

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Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus

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Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

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Properties of a novel thymidine kinase induced by an acyclovir-resistant herpes simplex virus type 1 mutant

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Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA

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Construction and characterization of a recombinant plasmid encoding the gene for the thymidine kinase of herpes simplex type 1 virus

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Sensitivity of Viruses to Phosphorylated 9-(2-hydroxyethoxymethyl)Guanine Revealed in TK-transformed Cells

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Properties of Herpes simplex virus type 1 and type 2 DNA polymerase

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A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus

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11 September 2019

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