(Q45888006)

17 December 2017

review article

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title

Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis (English)

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17 December 2017

1 reference

Dachs GU

1

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17 December 2017

Chaplin DJ

series ordinal

2

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17 December 2017

publication date

1 July 1998

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17 December 2017

Seminars in Radiation Oncology

published in

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17 December 2017

volume

8

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17 December 2017

page(s)

208-216

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17 December 2017

issue

3

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17 December 2017

Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases

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Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

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Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

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7 January 2021

Oxygen sensing and molecular adaptation to hypoxia

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7 January 2021

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer

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The experimental development of bioreductive drugs and their role in cancer therapy.

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7 January 2021

Targeting gene expression to hypoxic tumor cells

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7 January 2021

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

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7 January 2021

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

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7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

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7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

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7 January 2021

Structural and functional analysis of hypoxia-inducible factor 1.

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7 January 2021

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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7 January 2021

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

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7 January 2021

Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level

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7 January 2021

Co-transactivation of the 3' erythropoietin hypoxia inducible enhancer by the HIF-1 protein

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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7 January 2021

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase

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7 January 2021

A point mutation responsible for defective function of the aryl-hydrocarbon-receptor nuclear translocator in mutant Hepa-1c1c7 cells

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7 January 2021

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

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7 January 2021

Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells

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7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

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7 January 2021

Regulation of c-jun expression during hypoxic and low-glucose stress

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7 January 2021

Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes

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https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

The effects of hypoxia-ischemia on expression of c-Fos, c-Jun and Hsp70 in the young rat hippocampus.

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7 January 2021

In vivo carbon monoxide exposure and hypoxic hypoxia stimulate immediate early gene expression

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7 January 2021

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

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7 January 2021

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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7 January 2021

Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia

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7 January 2021

Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind Jun D, c-Fos, and Fra-2.

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7 January 2021

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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7 January 2021

Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level.

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

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7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

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https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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7 January 2021

Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

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https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects

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https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Regulation of endothelial nitric-oxide synthase during hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Reciprocal relation between VEGF and NO in the regulation of endothelial integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Nitric oxide inhibits migration of cultured endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Roles of nitric oxide in tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Evidence that nitric oxide is an endogenous antiangiogenic mediator

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1053-4296%2898%2980046-5

7 January 2021

10.1016/S1053-4296(98)80046-5

Identifiers

DOI

1 reference

17 December 2017

PubMed ID

9634497

1 reference

17 December 2017