(Q46061580)

19 December 2017

title

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate (English)

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19 December 2017

Solute carrier family 19 (folate transporter), member 1

main subject

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GOA release 2020-03-11

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Tse A

1

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19 December 2017

Brigle K

series ordinal

2

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19 December 2017

Taylor SM

series ordinal

3

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19 December 2017

Moran RG

series ordinal

4

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19 December 2017

language of work or name

English

0 references

publication date

1 October 1998

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19 December 2017

Journal of Biological Chemistry

published in

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19 December 2017

volume

273

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19 December 2017

page(s)

25953-25960

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19 December 2017

issue

40

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19 December 2017

Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25953

21 January 2018

Identifiers

DOI

10.1074/JBC.273.40.25953

1 reference

19 December 2017

PubMed ID

9748272

1 reference

19 December 2017