(Q46061653)

19 December 2017

title

Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents (English)

1 reference

19 December 2017

1 reference

Leisa Johnson

1

1 reference

19 December 2017

Annie Shen

2

1 reference

19 December 2017

Larry Boyle

3

1 reference

19 December 2017

John Kunich

4

1 reference

19 December 2017

Kusum Pandey

5

1 reference

19 December 2017

Marilyn Lemmon

6

1 reference

19 December 2017

Terry Hermiston

7

1 reference

19 December 2017

Marty Giedlin

8

1 reference

19 December 2017

Frank McCormick

9

1 reference

19 December 2017

Ali Fattaey

10

1 reference

19 December 2017

publication date

1 May 2002

1 reference

19 December 2017

published in

Cancer Cell

1 reference

19 December 2017

volume

1

1 reference

19 December 2017

page(s)

325-337

1 reference

19 December 2017

issue

4

1 reference

19 December 2017

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The retinoblastoma protein pathway in cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Infection of Mouse Liver by Human Adenovirus Type 5

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Adenovirus E1A makes two distinct contacts with the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

CDK inhibition and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The Rb/E2F pathway: expanding roles and emerging paradigms

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Gene delivery from the E3 region of replicating human adenovirus: evaluation of the E3B region

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Gene delivery from the E3 region of replicating human adenovirus: evaluation of the ADP region

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Regulation of cell proliferation by the E2F transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Role of E2F in cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

An adenovirus type 5 early gene function regulates expression of other early viral genes

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Cancer gene therapy: fringe or cutting edge?

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Oncogenic potential of the adenovirus E4orf6 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

DNA tumor virus transforming proteins and the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Targets for cancer therapy in the cell cycle pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Cellular targets for transformation by the adenovirus E1A proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900060-0

7 January 2021

10.1016/S1535-6108(02)00060-0

Identifiers

DOI

1 reference

19 December 2017

PubMed ID

12086848

1 reference

19 December 2017