(Q46212774)

20 December 2017

title

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action (English)

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20 December 2017

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4

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20 December 2017

Jerrold M. Olefsky

5

object named as

Jerrold M Olefsky

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20 December 2017

Emilie A Bard-Chapeau

1

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20 December 2017

Andrea L Hevener

2

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20 December 2017

Shinong Long

3

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20 December 2017

Gen-Sheng Feng

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20 December 2017

language of work or name

English

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publication date

10 April 2005

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20 December 2017

published in

Nature Medicine

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20 December 2017

volume

11

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20 December 2017

page(s)

567-571

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20 December 2017

issue

5

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20 December 2017

https://scigraph.springernature.com/pub.10.1038/nm1227

exact match

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cites work

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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

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Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

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DNA excision in liver by an albumin-Cre transgene occurs progressively with age

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

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Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

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A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

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7 January 2021

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

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7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase.

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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7 January 2021

Colorimetric Method for Determination of Sugars and Related Substances

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7 January 2021

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

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7 January 2021

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes

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7 January 2021

Influences of glucose loading and of injected insulin on hepatic glucose output

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Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis.

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7 January 2021

Identifiers

DOI

10.1038/NM1227

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20 December 2017

PubMed ID

15821749

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20 December 2017