(Q46473246)

22 December 2017

title

Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity (English)

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22 December 2017

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6

Gideon Koren

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22 December 2017

author name string

Katarina Aleksa

1

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22 December 2017

Doug Matsell

2

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22 December 2017

Kris Krausz

3

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22 December 2017

Harry Gelboin

4

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22 December 2017

Shinya Ito

5

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22 December 2017

publication date

4 May 2005

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22 December 2017

published in

Pediatric Nephrology

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22 December 2017

volume

20

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22 December 2017

page(s)

872-885

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22 December 2017

issue

7

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s00467-004-1807-3

exact match

0 references

cites work

Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development

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The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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Fractionated ifosfamide therapy produces a time-dependent increase in ifosfamide metabolism

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Inhibitory monoclonal antibody to human cytochrome P450 2B6.

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Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration

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Monooxygenase activities of human liver, lung, and kidney microsomes - a study of 42 post mortem cases

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Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones

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Monospecific antipeptide antibody to cytochrome P-450 2B6

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Renal cortical accumulation of phenobarbital in rats and rabbits: lack of correlation with induction of renal microsomal monooxygenases

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Benzoic acid glycine conjugation in the isolated perfused rat kidney

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Regional differences in peroxidatic activation of paracetamol (acetaminophen) mediated by cytochrome P450 and prostaglandin endoperoxide synthetase in rabbit kidney

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12 December 2020

Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes

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12 December 2020

The N-dechloroethylation of ifosfamide: using stereochemistry to obtain an accurate picture of a clinically relevant metabolic pathway

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Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.

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Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

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Expression of cytochrome P450 3A in amphibian, rat, and human kidney

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Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo

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Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

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12 December 2020

Changes in content of P450 isozymes in hepatic and renal microsomes of the male rat treated with cis-diamminedichloroplatinum

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12 December 2020

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

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12 December 2020

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

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12 December 2020

Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney

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12 December 2020

Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.

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12 December 2020

Bimodal distribution of renal cytochrome P450 3A activity in humans.

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12 December 2020

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

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12 December 2020

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

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12 December 2020

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

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12 December 2020

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

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12 December 2020

Molecular basis of ethnic differences in drug disposition and response

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12 December 2020

Human CYP2B6: expression, inducibility and catalytic activities

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12 December 2020

Effect of sodium alterations on hepatic cytochrome P450 3A2 and 2C11 and renal function in rats

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12 December 2020

Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer

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A discontinuous and highly porous sodium dodecyl sulfate-polyacrylamide slab gel system of high resolution

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Renal ontogeny of ifosfamide nephrotoxicity

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Angiotensin-converting enzyme inhibitor fetopathy

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12 December 2020

Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers

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12 December 2020

Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children

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12 December 2020

Ifosfamide nephrotoxicity in children: histopathological features in two cases

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12 December 2020

Developmental expression of cytochrome P450 enzymes in human liver.

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12 December 2020

Developmental expression of the major human hepatic CYP3A enzymes

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12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

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12 December 2020

Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels

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12 December 2020

Functional cytochrome P4503A isoforms in human embryonic tissues: expression during organogenesis.

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12 December 2020

Renal drug metabolism

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12 December 2020

Chemical stability and fate of the cytostatic drug ifosfamide and its N-dechloroethylated metabolites in acidic aqueous solutions

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12 December 2020

Lauric acid hydroxylation in human liver and kidney cortex microsomes

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12 December 2020

Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

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12 December 2020

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites

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12 December 2020

Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach

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12 December 2020

Renal clearance of ifosfamide

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12 December 2020

Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity

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12 December 2020

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling

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12 December 2020

Update: clinically significant cytochrome P-450 drug interactions

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12 December 2020

Ifosfamide clinical pharmacokinetics

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12 December 2020

Ontogeny of hepatic and renal systemic clearance pathways in infants: part I.

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12 December 2020

Influence of dose and infusion duration on pharmacokinetics of ifosfamide and metabolites

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12 December 2020

Rapid method for the determination of ifosfamide and cyclophosphamide in plasma by high-performance liquid chromatography with solid-phase extraction

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12 December 2020

Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy

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12 December 2020

A systematic study on the chemical stability of ifosfamide

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12 December 2020

Renal physiology Part 1: Structure and function.

1 reference

12 December 2020

10.1007/S00467-004-1807-3

Identifiers

DOI

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22 December 2017

PubMed ID

15875221

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22 December 2017