(Q46493853)

English

Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus

scientific article published in October 2008

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus (English)

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

phosphorylation

1 reference

based on heuristic

inferred from title

insulin resistance

1 reference

based on heuristic

inferred from title

object named as

Psammomys obesus

1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

author name string

Esther Mack

1

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Ehud Ziv

2

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Hadas Reuveni

3

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Rony Kalman

4

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Anne Jörns

6

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Sigurd Lenzen

7

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Eleazar Shafrir

8

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

publication date

1 October 2008

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Diabetes - Metabolism: Research and Reviews

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

24

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

577-584

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

7

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

Psammomys obesus of the Jerusalem colony: a model for nutritionally induced, non-insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

21 January 2018

Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to beta-cell apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat).

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence-based design of kinase inhibitors applicable for therapeutics and target identification

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

1 reference

https://api.crossref.org/works/10.1002%2FDMRR.881

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/DMRR.881

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18613220

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