(Q46522042)

22 December 2017

review article

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title

T-cell-antigen recognition and the immunological synapse (English)

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22 December 2017

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Johannes B Huppa

1

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22 December 2017

Mark M Davis

series ordinal

2

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22 December 2017

publication date

1 December 2003

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22 December 2017

Nature Reviews Immunology

published in

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22 December 2017

volume

3

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22 December 2017

page(s)

973-983

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22 December 2017

issue

12

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22 December 2017

Regulation of B-lymphocyte activation, proliferation, and differentiation.

cites work

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Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes

31 March 2020

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Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets

31 March 2020

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

31 March 2020

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Three-dimensional segregation of supramolecular activation clusters in T cells

31 March 2020

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Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium

31 March 2020

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Polarity of T cell shape, motility, and sensitivity to antigen

31 March 2020

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Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

31 March 2020

1 reference

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

31 March 2020

1 reference

The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

1 reference

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

31 March 2020

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The minimal number of class II MHC-antigen complexes needed for T cell activation

31 March 2020

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The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells

31 March 2020

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Direct observation of ligand recognition by T cells.

31 March 2020

1 reference

Crystal structure of R-phycoerythrin from Polysiphonia urceolata at 2.8 A resolution

31 March 2020

1 reference

Single-molecule fluorescence detection: autocorrelation criterion and experimental realization with phycoerythrin

31 March 2020

1 reference

Gene regulation mediated by calcium signals in T lymphocytes

31 March 2020

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

31 March 2020

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

31 March 2020

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T cell adhesion lowers the threshold for antigen detection

31 March 2020

1 reference

The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

31 March 2020

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Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules

31 March 2020

1 reference

Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples

31 March 2020

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A receptor/cytoskeletal movement triggered by costimulation during T cell activation

31 March 2020

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T lymphocyte costimulation mediated by reorganization of membrane microdomains

31 March 2020

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Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

31 March 2020

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The structure and ligand interactions of CD2: implications for T-cell function

31 March 2020

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Making the T cell receptor go the distance: a topological view of T cell activation

31 March 2020

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Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex

31 March 2020

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Synaptic pattern formation during cellular recognition

31 March 2020

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Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse

31 March 2020

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A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

31 March 2020

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Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

31 March 2020

1 reference

Staging and resetting T cell activation in SMACs

31 March 2020

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The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

31 March 2020

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Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin

31 March 2020

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ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

31 March 2020

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Polar redistribution of the sialoglycoprotein CD43: implications for T cell function

31 March 2020

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Physiological regulation of the immunological synapse by agrin

31 March 2020

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

31 March 2020

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Differential clustering of CD4 and CD3zeta during T cell recognition

31 March 2020

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Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

31 March 2020

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ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation

31 March 2020

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Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein

31 March 2020

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

31 March 2020

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

31 March 2020

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T cell receptor signaling precedes immunological synapse formation

31 March 2020

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The immunological synapse balances T cell receptor signaling and degradation

31 March 2020

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

31 March 2020

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The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering

31 March 2020

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Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling

31 March 2020

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Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells

31 March 2020

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Dynamic imaging of T cell-dendritic cell interactions in lymph nodes

31 March 2020

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Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential

31 March 2020

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Two-photon imaging of lymphocyte motility and antigen response in intact lymph node

31 March 2020

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Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

31 March 2020

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The duration of antigenic stimulation determines the fate of naive and effector T cells.

31 March 2020

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Molecular basis of T cell inactivation by CTLA-4

31 March 2020

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CTLA-4: new insights into its biological function and use in tumor immunotherapy

31 March 2020

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

31 March 2020

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CD8+ T Cell Effector Mechanisms in Resistance to Infection

31 March 2020

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

31 March 2020

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Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo

31 March 2020

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Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

31 March 2020

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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

31 March 2020

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Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection

31 March 2020

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Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation

31 March 2020

1 reference

Dendritic cells and the control of immunity

31 March 2020

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The danger model: a renewed sense of self

31 March 2020

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Activation of lysosomal function during dendritic cell maturation

31 March 2020

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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.

31 March 2020

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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

31 March 2020

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TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers.

31 March 2020

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Recruitment of HIV and its receptors to dendritic cell-T cell junctions.

31 March 2020

1 reference

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

31 March 2020

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The immunological synapse: required for T cell receptor signalling or directing T cell effector function?

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1245

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22 December 2017

PubMed ID

14647479

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22 December 2017