(Q4654858)

P-type ATPase, subfamily IB

1 reference

Heavy metal-associated domain superfamily

1 reference

P-type ATPase, cytoplasmic domain N

1 reference

P-type ATPase, transmembrane domain superfamily

1 reference

HAD-like superfamily

1 reference

Transporter Classification Database ID

P-type ATPase

1 reference

3.A.3.5.6

retrieved

2 October 2019

hierarchical database ID heuristic

Heavy metal-associated domain, HMA, protein family

1 reference

inferred from protein domain or family

Heavy metal-associated domain, copper ion-binding domain, protein family

1 reference

inferred from protein domain or family

Heavy-metal-associated, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

ATPase-coupled cation transmembrane transporter activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

superoxide dismutase copper chaperone activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

copper-dependent protein binding

1 reference

8 April 2019

Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

4 references

8 April 2019

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

P-type divalent copper transporter activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

copper ion transmembrane transporter activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

P-type divalent copper transporter activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

trans-Golgi network transport vesicle

IBA

cell component

1 reference

8 April 2019

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

26 September 2017

Biochemical characterization and intracellular localization of the Menkes disease protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

26 September 2017

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

endoplasmic reticulum

IDA

perinuclear region of cytoplasm

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

26 September 2017

Expression of menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

26 September 2017

Biochemical characterization and intracellular localization of the Menkes disease protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

26 September 2017

Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

IDA

brush border membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

phagocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

endoplasmic reticulum

1 reference

8 April 2019

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Biochemical characterization and intracellular localization of the Menkes disease protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

perinuclear region of cytoplasm

IBA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Expression of menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Biochemical characterization and intracellular localization of the Menkes disease protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

norepinephrine metabolic process

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

response to iron(III) ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

removal of superoxide radicals

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

detoxification of copper ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

neuron projection morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

pyramidal neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

extracellular matrix organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

collagen fibril organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

dopamine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

T-helper cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

tryptophan metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

regulation of oxidative phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cartilage development

1 reference

8 April 2019

response to copper ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of oxidoreductase activity

1 reference

8 April 2019

The Menkes copper transporter is required for the activation of tyrosinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

serotonin metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

blood vessel development

1 reference

8 April 2019

mitochondrion organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cerebellar Purkinje cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

elastic fiber assembly

1 reference

8 April 2019

central nervous system neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

lung alveolus development

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

blood vessel remodeling

1 reference

8 April 2019

peptidyl-lysine modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

catecholamine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

hair follicle morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

plasma membrane copper ion transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

epinephrine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

elastin biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

negative regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

response to manganese ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of lamellipodium assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

antimicrobial humoral response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

negative regulation of iron ion transmembrane transport

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to platelet-derived growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of cell size

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to amino acid stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to antibiotic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to cadmium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to cobalt ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to copper ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to iron ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to lead ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of response to wounding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

positive regulation of vascular associated smooth muscle cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

regulation of cytochrome-c oxidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04656

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04656&geneProductId=UniProtKB:Q04656

3 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

3.A.3.5.6

2 references

Transporter Classification database

retrieved

13 March 2020