(Q46556532)

English

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies

scientific article published in January 2005

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Evan D Kharasch

1

object named as

Evan D Kharasch

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

author name string

Dale Whittington

2

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Christine Hoffer

3

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Kevin Krudys

4

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Keith Craig

5

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Paolo Vicini

6

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Pam Sheffels

7

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Bojan Lalovic

8

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

publication date

1 January 2005

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

44

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

7

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

731-751

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-1-Acetylmethadol and its N-demethylated metabolites have potent opiate action in the guinea pig isolated ileum

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 3-year progress report on the implementation of LAAM in the United States.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

l-Acetylmethadol (LAM) treatment of opiate dependence: plasma and urine levels of two pharmacologically active metabolites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phenobarbital pretreatment on the plasma and urinary levels of (-)-alpha-acetylmethadol and its metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction with levomethadyl acetate: safety and efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma l-alpha-Acetylmethadol (LAAM) after acute and chronic administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cortisol, methylprednisolone, and methylprednisolone hemisuccinate. Absence of effects of troleandomycin on ester hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolite kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methadone vs. L-alpha-acetylmethadol (LAAM) in the treatment of opiate addiction. A meta-analysis of the randomized, controlled trials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary, secondary, and tertiary metabolite kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ondansetron does not affect alfentanil-induced ventilatory depression or sedation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between LAAM-methadone preference and treatment outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and urine disposition of 1-alpha-acetylmethadol and its principal metabolites in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of acetylmethadol in relation to pharmacologic action

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions between opioids and antiretroviral medications: interaction between methadone, LAAM, and nelfinavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LAAM maintenance vs methadone maintenance for heroin dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modelling of individual pharmacokinetics for computer-aided drug dosage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous and oral l-alpha-acetylmethadol: pharmacodynamics and pharmacokinetics in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention and treatment of postoperative nausea and vomiting

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alteration of metabolism on the analgesic activity, toxicity, distribution and excretion of l-alpha-acetylmethadol in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug abuse treatment as an HIV prevention strategy: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

History and current status of opioid maintenance treatments: blending conference session

1 reference

https://pubmed.ncbi.nlm.nih.gov/15966756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200544070-00005

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/15966756

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