(Q46677125)

English

EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids

scientific article published on 31 March 2008

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scholarly article

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids (English)

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

author name string

Z Chen

1

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

J Feng

2

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

J-S Saldivar

3

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

D Gu

4

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

A Bockholt

5

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

S S Sommer

6

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

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publication date

31 March 2008

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

27

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Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

4336-4343

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

31

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Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

https://scigraph.springernature.com/pub.10.1038/onc.2008.71

0 references

Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

1 reference

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21 January 2018

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Patterns of somatic mutation in human cancer genomes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Spontaneous tandem-base mutations (TBM) show dramatic tissue, age, pattern and spectrum specificity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Amplification, mutation and loss of heterozygosity of the EGFR gene in metastatic lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

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21 January 2018

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Enhancement of radiosensitivity in head and neck cancer cells by ZD1839 ('IRESSA'), a selective epidermal growth factor receptor tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

The consensus coding sequences of human breast and colorectal cancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

The size distributions of proteins, mRNA, and nuclear RNA.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Role in tumorigenesis of silent mutations in the TP53 gene.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

21 January 2018

Somatic mutations of the protein kinase gene family in human lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

31 March 2020

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

31 March 2020

Silent and multiple mutations in p53 and the question of the hypermutability of tumors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.71

31 March 2020

Identifiers

10.1038/ONC.2008.71

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/18372921

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