(Q46890874)

English

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

scientific article published in May 2006

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15 January 2020

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine (English)

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15 January 2020

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15 January 2020

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T Furuta

1

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15 January 2020

R L Hayward

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15 January 2020

L-H Meng

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15 January 2020

H Takemura

4

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15 January 2020

W M Bonner

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15 January 2020

M I Aladjem

7

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15 January 2020

K W Kohn

8

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15 January 2020

Y Pommier

9

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1 May 2006

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15 January 2020

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15 January 2020

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15 January 2020

2839-2849

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15 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209313

0 references

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Checkpoints: How to activate p53

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

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Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.

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21 January 2018

Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage

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Impairment of homologous recombination control in a Fanconi anemia-like Chinese hamster cell mutant

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Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints

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21 January 2018

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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A unified view of the DNA-damage checkpoint

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DNA damage tumor suppressor genes and genomic instability

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

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The G2-phase DNA-damage checkpoint

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Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site

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Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

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Repair of and checkpoint response to topoisomerase I-mediated DNA damage

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

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Histone H2A variants H2AX and H2AZ

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