(Q47576146)

4 February 2018

title

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture. (English)

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4 February 2018

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2

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Filipa L Sousa

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4 February 2018

Sarah Teichmann

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4 February 2018

Tina Perica

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object named as

Tina Perica

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4 February 2018

Sebastian E. Ahnert

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object named as

Sebastian E Ahnert

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4 February 2018

author name string

Eviatar Natan

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4 February 2018

Lucy J Colwell

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4 February 2018

publication date

1 June 2012

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4 February 2018

Biochemical Society Transactions

published in

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4 February 2018

volume

40

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4 February 2018

page(s)

475-491

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4 February 2018

issue

3

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4 February 2018

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

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X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli

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Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance

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Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.

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Molecular dynamics simulation of the SH3 domain aggregation suggests a generic amyloidogenesis mechanism

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3D domain swapping: as domains continue to swap

21 January 2018

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An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression

21 January 2018

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Dimerization as a regulatory mechanism in signal transduction

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

The role of dimerization in noise reduction of simple genetic networks.

21 January 2018

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Cells in stress: transcriptional activation of heat shock genes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Structural evolution of C-terminal domains in the p53 family

21 January 2018

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How p53 binds DNA as a tetramer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Cooperative binding of tetrameric p53 to DNA.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

The expanding universe of p53 targets

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Biochemical and genetic properties of oligomeric structures: a general approach.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Dominant-negative p53 mutations selected in yeast hit cancer hot spots

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Ultraslow oligomerization equilibria of p53 and its implications

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Complementation of two mutant p53: implications for loss of heterozygosity in cancer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Mutational robustness can facilitate adaptation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

The importance of sequence diversity in the aggregation and evolution of proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Emergence of symmetry in homooligomeric biological assemblies.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Evolution of function in protein superfamilies, from a structural perspective.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Specificity and evolvability in eukaryotic protein interaction networks

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

A simple definition of structural regions in proteins and its use in analyzing interface evolution.

21 January 2018

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21 January 2018

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Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Designed protein-protein association

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Correlation of co-ordinated amino acid substitutions with function in viruses related to tobacco mosaic virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

How frequent are correlated changes in families of protein sequences?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Evolutionarily conserved pathways of energetic connectivity in protein families

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Effectiveness of correlation analysis in identifying protein residues undergoing correlated evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Detecting coevolution in and among protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Rewiring the specificity of two-component signal transduction systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Mutual information without the influence of phylogeny or entropy dramatically improves residue contact prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Protein sectors: evolutionary units of three-dimensional structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Accurate prediction of protein-protein interactions from sequence alignments using a Bayesian method

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Disentangling direct from indirect co-evolution of residues in protein alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Identification of direct residue contacts in protein-protein interaction by message passing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Protein 3D structure computed from evolutionary sequence variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

PIBASE: a comprehensive database of structurally defined protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

The origin of protein interactions and allostery in colocalization

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

ASD: a comprehensive database of allosteric proteins and modulators

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Conformational selection or induced fit: a flux description of reaction mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

A phase function to quantify serial dependence between discrete samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Simulations of allosteric transitions

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Residues crucial for maintaining short paths in network communication mediate signaling in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Allosteric communication occurs via networks of tertiary and quaternary motions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Uncovering network systems within protein structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Small-world communication of residues and significance for protein dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Local motions in a benchmark of allosteric proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

oGNM: online computation of structural dynamics using the Gaussian Network Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Dynamic allostery in the methionine repressor revealed by force distribution analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Allostery in the LacI/GalR family: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Crystal structure of the lactose operon repressor and its complexes with DNA and inducer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

A closer view of the conformation of the Lac repressor bound to operator

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not require a specific sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120056

Dynamic allostery: linkers are not merely flexible

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Using networks to identify fine structural differences between functionally distinct protein states

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structure-based predictive models for allosteric hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Positions 94-98 of the lactose repressor N-subdomain monomer-monomer interface are critical for allosteric communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Identification of key residues for protein conformational transition using elastic network model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Protein-protein complex structure predictions by multimeric threading and template recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Three-dimensional modeling of protein interactions and complexes is going 'omics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

The crystal structure of human deoxyhaemoglobin at 1.74 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structure of thiocyanate hydrolase: a new nitrile hydratase family protein with a novel five-coordinate cobalt(III) center

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Molecular architecture of the rotary motor in ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Relative solvent accessible surface area predicts protein conformational changes upon binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Intrinsically disordered proteins: regulation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Linking folding and binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structural disorder promotes assembly of protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Evolution of protein complexes by duplication of homomeric interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Protein interaction maps for complete genomes based on gene fusion events

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Detecting protein function and protein-protein interactions from genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Structures of the Klebsiella aerogenes urease apoenzyme and two active-site mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Supramolecular assembly and acid resistance of Helicobacter pylori urease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Relative rates of gene fusion and fission in multi-domain proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Ubiquitin-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Transient protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Quantitative, high-resolution proteomics for data-driven systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

RING: networking interacting residues, evolutionary information and energetics in protein structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

CMView: interactive contact map visualization and analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Network Analysis of Protein Structures Identifies Functional Residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

Complexity of Self‐Assembled Shapes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120056

21 January 2018

Identifiers

DOI

10.1042/BST20120056

1 reference

4 February 2018

PubMed ID

22616857

1 reference

4 February 2018