(Q47714483)

5 February 2018

review article

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title

GTPase-activating proteins: helping hands to complement an active site. (English)

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5 February 2018

author name string

Scheffzek K

series ordinal

1

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5 February 2018

Ahmadian MR

series ordinal

2

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5 February 2018

Wittinghofer A

series ordinal

3

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5 February 2018

publication date

1 July 1998

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5 February 2018

number of pages

6

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Trends in Biochemical Sciences

inferred from page(s)

published in

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5 February 2018

volume

23

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5 February 2018

page(s)

257-262

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5 February 2018

issue

7

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5 February 2018

The GTPase superfamily: a conserved switch for diverse cell functions

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The GTPase superfamily: conserved structure and molecular mechanism

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Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

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Proteins regulating Ras and its relatives

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Function and regulation of ras.

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The neurofibromatosis type 1 gene and its protein product, neurofibromin.

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7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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7 January 2021

RGS proteins and signaling by heterotrimeric G proteins

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7 January 2021

Structural aspects of protein synthesis

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7 January 2021

Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases

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7 January 2021

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

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7 January 2021

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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7 January 2021

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

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7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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7 January 2021

Aluminum fluoride associates with the small guanine nucleotide binding proteins.

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7 January 2021

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

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7 January 2021

The structure of the GTPase-activating domain from p50rhoGAP

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7 January 2021

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

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7 January 2021

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

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7 January 2021

Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.

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7 January 2021

Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site

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7 January 2021

Is there a rate-limiting step before GTP cleavage by H-ras p21?

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7 January 2021

Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue

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7 January 2021

Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state

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7 January 2021

Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology

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7 January 2021

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

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7 January 2021

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

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7 January 2021

Signaling mechanistics: aluminum fluoride for molecule of the year

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7 January 2021

GAPs for rho-related GTPases

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7 January 2021

The interaction of Ras with GTPase-activating proteins

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7 January 2021

Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin

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7 January 2021

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

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7 January 2021

Biological and biochemical properties of human rasH genes mutated at codon 61.

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7 January 2021

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

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7 January 2021

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

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7 January 2021

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

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7 January 2021

Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190

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7 January 2021

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

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7 January 2021

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

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7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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7 January 2021

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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7 January 2021

Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy

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7 January 2021

X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

Raster3D: photorealistic molecular graphics

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7 January 2021

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

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7 January 2021

Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1

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7 January 2021

Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family

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7 January 2021

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

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7 January 2021

The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization

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7 January 2021

Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1).

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7 January 2021

10.1016/S0968-0004(98)01224-9

Identifiers

DOI

1 reference

5 February 2018

PubMed ID

9697416

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5 February 2018