(Q48176609)

9 February 2018

title

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil (English)

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9 February 2018

author

Oliver Langer

1

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9 February 2018

Alexander Hammers

3

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Raute Sunder-Plassmann

10

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Martin Bauer

object named as

Martin Bauer

2

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Fritz Zimprich

object named as

Friedrich Zimprich

11

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author name string

Rudolf Karch

4

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9 February 2018

Ekaterina Pataraia

5

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Matthias J Koepp

6

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Aiman Abrahim

7

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Gert Luurtsema

8

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Martin Brunner

9

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Christian Joukhadar

12

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Stephan Gentzsch

13

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Robert Dudczak

14

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Kurt Kletter

15

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Markus Müller

16

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Christoph Baumgartner

17

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publication date

1 May 2007

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9 February 2018

published in

Epilepsia

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9 February 2018

volume

48

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issue

9

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page(s)

1774-1784

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9 February 2018

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

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Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays

21 January 2018

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Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model.

21 January 2018

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Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

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Imaging P-glycoprotein at the human blood-brain barrier

21 January 2018

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Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe

21 January 2018

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 January 2018

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Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

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Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

21 January 2018

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In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

21 January 2018

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Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

21 January 2018

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How to explain multidrug resistance in epilepsy?

21 January 2018

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Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

21 January 2018

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Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

21 January 2018

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Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

21 January 2018

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Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

21 January 2018

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Carbamazepine is not a substrate for P-glycoprotein

21 January 2018

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In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

21 January 2018

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P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

21 January 2018

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Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

1 reference

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Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2007.01116.X

Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy

21 January 2018

1 reference

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

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Molecular and cellular mechanisms of pharmacoresistance in epilepsy

21 January 2018

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21 January 2018

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

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Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

21 January 2018

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Over-expression of P-glycoprotein in malformations of cortical development.

21 January 2018

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Simultaneous analysis of MDR1 C3435T, G2677T/A, and C1236T genotypes by multiplexed mutagenically separated PCR.

21 January 2018

1 reference

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Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

21 January 2018

1 reference

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Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

21 January 2018

1 reference

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Targeting multidrug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2007.01116.X

MDR1 gene expression in brain of patients with medically intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2007.01116.X

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2007.01116.X

Localization of Multidrug Transporter Substrates within Model Membranes†

21 January 2018

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Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2007.01116.X

10.1111/J.1528-1167.2007.01116.X

21 January 2018

Identifiers

DOI

1 reference

9 February 2018

1 reference

9 February 2018