(Q48275849)

English

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

scientific article published in March 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

author name string

Guo Q

1

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Sebastian L

2

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Sopher BL

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Miller MW

4

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Ware CB

5

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Martin GM

6

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Mattson MP

7

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

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publication date

1 March 1999

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

72

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

1019-1029

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Vitamin E protects nerve cells from amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

NMDA-dependent superoxide production and neurotoxicity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Evidence for synaptic apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

The role of the Caspase family of cysteine proteases in apoptosis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Calcium ionophore increases amyloid beta peptide production by cultured cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721019.X

21 January 2018

Identifiers

10.1046/J.1471-4159.1999.0721019.X

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/10037473

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