(Q4847910)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08172

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

G protein-coupled acetylcholine receptor activity

4 references

16 July 2018

Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

Activation and allosteric modulation of a muscarinic acetylcholine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

arrestin family protein binding

IDA

1 reference

8 April 2019

Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled receptor activity

IPI

G protein-coupled serotonin receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled acetylcholine receptor activity

5 references

8 April 2019

Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Activation and allosteric modulation of a muscarinic acetylcholine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

postsynaptic membrane

1 reference

8 April 2019

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

integral component of plasma membrane

IDA

3 references

16 July 2018

Identification of a family of muscarinic acetylcholine receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

Activation and allosteric modulation of a muscarinic acetylcholine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

clathrin-coated vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

integral component of membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation

GOA

curator

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

IDA

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

integral component of plasma membrane

4 references

8 April 2019

Identification of a family of muscarinic acetylcholine receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Activation and allosteric modulation of a muscarinic acetylcholine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled receptor signaling pathway

biological process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

16 July 2018

M(2) and M(4) muscarinic receptor subtypes couple to activation of endothelial nitric oxide synthase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

1 reference

8 April 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

synaptic transmission, cholinergic

IEP

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

nervous system development

1 reference

8 April 2019

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

1 reference

8 April 2019

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

membrane organization

1 reference

8 April 2019

regulation of heart contraction

3 references

16 July 2018

Presence of antibodies against the third intracellular loop of the m2 muscarinic receptor in the sera of chronic chagasic patients

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08172&geneProductId=UniProtKB:P08172

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

G protein-coupled serotonin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08172

physically interacts with

1 reference

294

17 August 2016

1 reference

296

17 August 2016

1 reference

297

17 August 2016

1 reference

57

17 August 2016

1 reference

305

17 August 2016

1 reference

342

17 August 2016

1 reference

345

17 August 2016

1 reference

349

17 August 2016

1 reference

346

17 August 2016

1 reference

7449

17 August 2016

2 references

3264

17 August 2016

368

17 August 2016

1 reference

200

17 August 2016

1 reference

7128

17 August 2016

1 reference

354

17 August 2016

1 reference

355

17 August 2016

1 reference

323

17 August 2016

1 reference

324

17 August 2016

1 reference

357

17 August 2016

methoctramine free base

has use

antagonist

1 reference

327

17 August 2016

1 reference

359

17 August 2016

1 reference

328

17 August 2016

1 reference

329

17 August 2016

1 reference

351

3-quinuclidinyl-benzilate

17 August 2016

has use

antagonist

1 reference

318

17 August 2016

1 reference

7354

17 August 2016

1 reference

7459

17 August 2016

1 reference

321

17 August 2016

1 reference

360

17 August 2016

1 reference

302

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1231

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1346

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1768

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1133

darifenacin hydrobromide

object has role

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200935

exact match

http://purl.uniprot.org/uniprot/P08172

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08172

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

4 April 2020

1 reference

4 April 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016