(Q48601563)

13 February 2018

title

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins (English)

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13 February 2018

author

Michael K Lee

4

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13 February 2018

author name string

Borchelt DR

1

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13 February 2018

Ratovitski T

2

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13 February 2018

van Lare J

3

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13 February 2018

Gonzales V

5

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13 February 2018

Jenkins NA

6

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13 February 2018

Copeland NG

7

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13 February 2018

Price DL

8

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13 February 2018

Sisodia SS

9

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13 February 2018

language of work or name

English

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publication date

1 October 1997

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13 February 2018

published in

Neuron

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13 February 2018

volume

19

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13 February 2018

issue

4

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13 February 2018

page(s)

939-945

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13 February 2018

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Mutation analysis of presenillin 1 gene in Alzheimer's disease.

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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Familial Alzheimer's disease associated with S182 codon 286 mutation

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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7 January 2021

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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7 January 2021

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

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7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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7 January 2021

Atrophic cell processes of large motor neurons in the anterior horn in amyotrophic lateral sclerosis: observation with silver impregnation method

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7 January 2021

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Genetic dissection of Alzheimer disease, a heterogeneous disorder

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Alzheimer's disease: genotypes, phenotypes, and treatments

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

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7 January 2021

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980974-5

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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7 January 2021

Senile dementia of the Alzheimer type

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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7 January 2021

Familial Alzheimer's chromosome 14 mutations

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7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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7 January 2021

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980974-5

7 January 2021

10.1016/S0896-6273(00)80974-5

Identifiers

DOI

1 reference

13 February 2018

1 reference

13 February 2018