(Q48624305)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

Janice L Hallows

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Robert E Iosif

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Rebecca D Biasell

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Inez Vincent

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

1 March 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

2738-2744

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

17 January 2020

cites work

1 reference

12 December 2020

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

12 December 2020

Embryonic Striatal Neurons from Niemann-Pick Type C Mice Exhibit Defects in Cholesterol Metabolism and Neurotrophin Responsiveness

1 reference

12 December 2020

Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

1 reference

12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

12 December 2020

Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease

1 reference

12 December 2020

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

12 December 2020

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

1 reference

12 December 2020

Neurobiology: p25 protein in neurodegeneration

1 reference

12 December 2020

Neurodegenerative tauopathies

1 reference

12 December 2020

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

1 reference

12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

1 reference

12 December 2020

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

1 reference

12 December 2020

Studies on neuronal death in the mouse model of Niemann-Pick C disease

1 reference

12 December 2020

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

12 December 2020

Rescue of neurodegeneration in Niemann-Pick C mice by a prion-promoter-driven Npc1 cDNA transgene

1 reference

12 December 2020

Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles

1 reference

12 December 2020

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

1 reference

12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

12 December 2020

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

1 reference

12 December 2020

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

1 reference

12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

12 December 2020

Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.

1 reference

12 December 2020

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

12 December 2020

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

1 reference

12 December 2020

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

1 reference

12 December 2020

Consequences of NPC1 and NPC2 loss of function in mammalian neurons

1 reference

12 December 2020

Tau pathology in Alzheimer disease and other tauopathies

1 reference

12 December 2020

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

1 reference

12 December 2020

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

1 reference

12 December 2020

Neurofibrillary axonal swellings and amyotrophic lateral sclerosis

1 reference

12 December 2020

Hereditary diffuse leucoencephalopathy with spheroids

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases by purine analogues

1 reference

12 December 2020

Phosphorylation of neurofilament H subunit as related to arrangement of neurofilaments.

1 reference

12 December 2020

A brain-specific activator of cyclin-dependent kinase 5.

1 reference

12 December 2020

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

12 December 2020

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain

1 reference

12 December 2020

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1 reference

12 December 2020

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

12 December 2020

Frontotemporal dementia: neuropil spheroids and presynaptic terminal degeneration

1 reference

12 December 2020

10.1523/JNEUROSCI.4834-05.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16525053%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

16525053

1 reference