Wikidata

(Q5005897)

English

MET proto-oncogene, receptor tyrosine kinase

mammalian protein found in Homo sapiens

  • proto-oncogene c-Met
  • scatter factor receptor
  • MET
  • hepatocyte growth factor receptor
  • HGF receptor
  • PTPRZ1/MET fusion
  • HGF/SF receptor
  • tyrosine-protein kinase Met
  • SF receptor
  • Proto-Oncogene Proteins c-met
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
33 references
retrieved
9 May 2019
stated in
Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold
GOA
curator
UniProt
UniProt protein ID
P08581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity
GOA
curator
UniProt
UniProt protein ID
P08581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
P08581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor
GOA
curator
UniProt
UniProt protein ID
P08581
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for agonism and antagonism of hepatocyte growth factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
EGFR/Met association regulates EGFR TKI resistance in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Interplay between scatter factor receptors and B plexins controls invasive growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Effect of cancer-associated mutations in the PlexinB1 gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis of hepatocyte growth factor/scatter factor and MET signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
retrieved
9 May 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08581
determination method
IPI
cell component
biological process
physically interacts with
Gene Atlas image
PBB GE MET 213816 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D019859
subject named as
Proto-Oncogene Proteins c-met
0 references
Freebase ID
/m/0852c8
0 references
PDB structure ID
 
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