(Q50287329)

English

RNF8 and RNF168 ubiquitinate H2AFX

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5682858)

In more languages

default for all languages

No label defined

No description defined

edit

Statements

1 reference

8 July 2022

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5682858

1 reference

8 July 2022

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

12

object of statement has role

1 reference

8 July 2022

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

1 reference

8 July 2022

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

1 reference

8 July 2022

Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation

1 reference

8 July 2022

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

1 reference

8 July 2022

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

1 reference

8 July 2022

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50287329)

RNF8 and RNF168 ubiquitinate H2AFX

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)