(Q50297299)

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Caspase-8 and FLIP(L) processing at DISC

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-3465448)

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8 July 2022

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-3465448

1 reference

8 July 2022

DISC:procaspase-8:FLIP(L) [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

CASP8 and FADD like apoptosis regulator

quantity

1

object of statement has role

1 reference

8 July 2022

DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

active caspase-8 [cytosol]

quantity

1

object of statement has role

1 reference

8 July 2022

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

1 reference

8 July 2022

Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation

1 reference

8 July 2022

Mechanism of procaspase-8 activation by c-FLIPL

1 reference

8 July 2022

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

1 reference

8 July 2022

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

1 reference

8 July 2022

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50297299)

Caspase-8 and FLIP(L) processing at DISC

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