(Q50308475)

2 March 2018

review article

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title

The mitochondrial uncoupling-protein homologues. (English)

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2 March 2018

oxidative phosphorylation uncoupler activity

main subject

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Gene Ontology release 2020-05-02

Stefan Krauss

1

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2 March 2018

Chen-Yu Zhang

series ordinal

2

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2 March 2018

Bradford B Lowell

series ordinal

3

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2 March 2018

publication date

1 March 2005

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2 March 2018

Nature Reviews Molecular Cell Biology

published in

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2 March 2018

volume

6

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2 March 2018

page(s)

248-261

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2 March 2018

issue

3

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2 March 2018

https://scigraph.springernature.com/pub.10.1038/nrm1592

exact match

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cites work

Purification and properties of mitochondrial adenosine triphosphatase of hamster brown adipose tissue

1 reference

Brown adipose tissue mitochondria

21 January 2018

1 reference

Mitochondrial proton leak and the uncoupling protein 1 homologues.

21 January 2018

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Reactive oxygen species, mitochondria, apoptosis and aging.

31 March 2020

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Mitochondrial uncoupling proteins in mammals and plants

31 March 2020

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

31 March 2020

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

31 March 2020

1 reference

UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

31 March 2020

1 reference

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

31 March 2020

1 reference

The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups

31 March 2020

1 reference

Thermogenic mechanisms in brown fat

31 March 2020

1 reference

Brown adipose tissue: function and physiological significance

31 March 2020

1 reference

Stimulation of glucose transport by insulin and norepinephrine in isolated rat brown adipocytes

31 March 2020

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Insulin and noradrenaline independently stimulate the translocation of glucose transporters from intracellular stores to the plasma membrane in mouse brown adipocytes

31 March 2020

1 reference

The mitochondrial ATPase of brown adipose tissue Purification and comparison with the mitochondrial ATPase from beef heart

31 March 2020

1 reference

Structure and function of the uncoupling protein from brown adipose tissue

31 March 2020

1 reference

The mechanism of proton transport mediated by mitochondrial uncoupling proteins

31 March 2020

1 reference

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

31 March 2020

1 reference

On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

31 March 2020

1 reference

Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.

31 March 2020

1 reference

The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter.

31 March 2020

1 reference

How do uncoupling proteins uncouple?

31 March 2020

1 reference

Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism

31 March 2020

1 reference

Coenzyme Q is an obligatory cofactor for uncoupling protein function

31 March 2020

1 reference

Brown-Adipose-Tissue Mitochondria: Photoaffinity Labelling of the Regulatory Site of Energy Dissipation

31 March 2020

1 reference

Hamster Brown-Adipose-Tissue Mitochondria. Purine Nucleotide Control of the Ion Conductance of the Inner Membrane, the Nature of the Nucleotide Binding Site

31 March 2020

1 reference

Uncoupling proteins 1 and 3 are regulated differently

31 March 2020

1 reference

Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression.

31 March 2020

1 reference

Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

31 March 2020

1 reference

The uncoupling proteins, a review.

31 March 2020

1 reference

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

31 March 2020

1 reference

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

31 March 2020

1 reference

Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.

31 March 2020

1 reference

Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

31 March 2020

1 reference

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

31 March 2020

1 reference

Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria

31 March 2020

1 reference

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

31 March 2020

1 reference

Superoxide activates mitochondrial uncoupling proteins

31 March 2020

1 reference

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

31 March 2020

1 reference

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

31 March 2020

1 reference

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3

31 March 2020

1 reference

Energy metabolism in uncoupling protein 3 gene knockout mice

31 March 2020

1 reference

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

31 March 2020

1 reference

In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism

31 March 2020

1 reference

Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.

31 March 2020

1 reference

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

31 March 2020

1 reference

Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein

31 March 2020

1 reference

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

31 March 2020

1 reference

Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3.

31 March 2020

1 reference

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

31 March 2020

1 reference

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

31 March 2020

1 reference

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

31 March 2020

1 reference

Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice

31 March 2020

1 reference

Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage

31 March 2020

1 reference

Pharmacology: uncoupling the agony from ecstasy

31 March 2020

1 reference

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter

31 March 2020

1 reference

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

31 March 2020

1 reference

Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.

31 March 2020

1 reference

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes

31 March 2020

1 reference

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

31 March 2020

1 reference

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

31 March 2020

1 reference

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

31 March 2020

1 reference

A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

31 March 2020

1 reference

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells.

31 March 2020

1 reference

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

31 March 2020

1 reference

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3.

31 March 2020

1 reference

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

31 March 2020

1 reference

Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

31 March 2020

1 reference

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

31 March 2020

1 reference

Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

31 March 2020

1 reference

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

31 March 2020

1 reference

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

31 March 2020

1 reference

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

31 March 2020

1 reference

Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells

31 March 2020

1 reference

Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells

31 March 2020

1 reference

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

31 March 2020

1 reference

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

31 March 2020

1 reference

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

31 March 2020

1 reference

Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase

31 March 2020

1 reference

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

31 March 2020

1 reference

Correlation between pancreatic islet uncoupling protein-2 (UCP2) mRNA concentration and insulin status in rats.

31 March 2020

1 reference

Visualizing superoxide production in normal and diabetic rat islets of Langerhans

31 March 2020

1 reference

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

31 March 2020

1 reference

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

31 March 2020

1 reference

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c

31 March 2020

1 reference

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

31 March 2020

1 reference

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

31 March 2020

1 reference

Inhibition of glucose-induced insulin secretion by 4-hydroxy-2-nonenal and other lipid peroxidation products

31 March 2020

1 reference

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

31 March 2020

1 reference

The mitochondrial uncoupling protein UCP1: a gated pore

31 March 2020

1 reference

Structure-function relationship in UCP1

31 March 2020

1 reference

Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition

31 March 2020

1 reference

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

31 March 2020

1 reference

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.

31 March 2020

1 reference

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects

31 March 2020

1 reference

Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients

31 March 2020

1 reference

Biochemistry and molecular cell biology of diabetic complications

31 March 2020

1 reference

Mitochondrial function in normal and diabetic beta-cells

31 March 2020

1 reference

Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT).

31 March 2020

1 reference

Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

A time-efficient, linear-space local similarity algorithm

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1592

1 reference

2 March 2018

Dimensions Publication ID

0 references

1 reference

2 March 2018