(Q50698909)

17 March 2018

title

Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving non-linear tissue uptake. (English)

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17 March 2018

author name string

Robert Laplanche

series ordinal

1

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17 March 2018

Guy M L Meno-Tetang

series ordinal

2

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17 March 2018

Ryosei Kawai

series ordinal

3

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17 March 2018

publication date

13 March 2007

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17 March 2018

Journal of Pharmacokinetics and Pharmacodynamics

published in

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17 March 2018

volume

34

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17 March 2018

page(s)

373-400

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17 March 2018

issue

3

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17 March 2018

https://scigraph.springernature.com/pub.10.1007/s10928-007-9051-7

exact match

0 references

cites work

Species differences in sirolimus stability in humans, rabbits, and rats

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12 December 2020

Binding of a new vinca alkaloid derivative, S12363, to human plasma proteins and platelets. Usefulness of an erythrocyte partitioning technique

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12 December 2020

Physiologic modeling of cyclosporin kinetics in rat and man.

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Effect of SDZ RAD on transplant arteriosclerosis in the rat aortic model

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Anti-CD25 therapy reveals the redundancy of the intragraft cytokine network after clinical heart transplantation

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Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.

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12 December 2020

Immunopharmacology of rapamycin

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12 December 2020

Immunosuppressive profile of rapamycin.

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12 December 2020

Structural elucidation by electrospray mass spectrometry: an approach to the in vitro metabolism of the macrolide immunosuppressant SDZ RAD

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12 December 2020

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

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12 December 2020

Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats

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12 December 2020

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

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12 December 2020

The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens

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12 December 2020

Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.

1 reference

12 December 2020

In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin

1 reference

12 December 2020

Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats.

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

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12 December 2020

Tissue water content in rats measured by desiccation.

1 reference

12 December 2020

10.1007/S10928-007-9051-7

Identifiers

DOI

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17 March 2018

PubMed ID

17431753

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17 March 2018