(Q51236144)

English

Hairy Dmel_CG6494

Protein found in Drosophila melanogaster

h-PB
CG6494-PB
CG6494 gene product from transcript CG6494-RB
h-PA
CG6494-PA
hairy
barrel
h

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

28 February 2018

UniProt protein ID

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14003

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

protein binding

determination method

11 references

9 May 2019

Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteins.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

transcription factor binding

determination method

1 reference

9 May 2019

Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

protein dimerization activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

determination method

1 reference

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

4 references

10 September 2018

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

transcription corepressor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

sequence-specific double-stranded DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

biological process

negative regulation of transcription by RNA polymerase II

determination method

6 references

7 November 2018

Runt and Lozenge function in Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

7 November 2018

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

7 November 2018

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

7 November 2018

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

7 November 2018

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

7 November 2018

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

cell morphogenesis

determination method

1 reference

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

response to hypoxia

determination method

1 reference

9 May 2019

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

periodic partitioning by pair rule gene

determination method

4 references

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The origin and evolution of segmentation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Playing by pair-rules?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

nervous system development

determination method

1 reference

9 May 2019

The role of class I HLH genes in neural development--have they been overlooked?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

open tracheal system development

determination method

1 reference

9 May 2019

A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

salivary gland morphogenesis

determination method

3 references

9 May 2019

Constructing an organ: the Drosophila salivary gland as a model for tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

R8 cell fate commitment

determination method

1 reference

7 November 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

determination method

regulation of cellular metabolic process

determination method

1 reference

9 May 2019

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

tube morphogenesis

determination method

1 reference

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

posterior head segmentation

determination method

1 reference

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

trunk segmentation

determination method

1 reference

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

negative regulation of transcription, DNA-templated

determination method

4 references

9 May 2019

Transcriptional repression: the long and the short of it.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

membrane organization

determination method

1 reference

9 May 2019

Tube morphogenesis: no pipe dream in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

Notch signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

cell differentiation

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

regulation of neurogenesis

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

negative regulation of transcription by RNA polymerase II

determination method

5 references

8 April 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

8 April 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

8 April 2019

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

8 April 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

8 April 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

negative regulation of transcription by RNA polymerase II

determination method

6 references

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

anterior/posterior pattern specification

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

determination method

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14003

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14003

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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