(Q5198252)

Cyclin-dependent kinase 6

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

protein kinase activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

cyclin-dependent protein serine/threonine kinase activity

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534

27 February 2018

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534

protein serine/threonine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

23 references

8 April 2019

The protein interaction landscape of the human CMGC kinase group

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Interaction between Cdc37 and Cdk4 in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Functional characterization of human PFTK1 as a cyclin-dependent kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A p18 mutant defective in CDK6 binding in human breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Proteomic analysis of p16ink4a-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Self-assembling protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

3 references

FBXO family protein binding

1 reference

8 April 2019

Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

cyclin-dependent protein serine/threonine kinase activity

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

cyclin-dependent protein kinase holoenzyme complex

1 reference

8 April 2019

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

microtubule organizing center

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

cyclin D2-CDK6 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

lateral ventricle development

1 reference

8 April 2019

Cdk6-dependent regulation of G(1) length controls adult neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

positive regulation of cell-matrix adhesion

1 reference

8 April 2019

The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

positive regulation of fibroblast proliferation

1 reference

8 April 2019

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

dentate gyrus development

IMP

1 reference

8 April 2019

Cdk6-dependent regulation of G(1) length controls adult neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

regulation of erythrocyte differentiation

ISS

1 reference

8 April 2019

CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes

IMP

astrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of cell differentiation

ISS

1 reference

8 April 2019

Beyond the cell cycle: a new role for Cdk6 in differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of cell cycle

IEP

1 reference

8 April 2019

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of osteoblast differentiation

1 reference

8 April 2019

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

Cdk6-dependent regulation of G(1) length controls adult neurogenesis

generation of neurons

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

regulation of cell motility

1 reference

8 April 2019

Changes in motility, gene expression and actin dynamics: Cdk6-induced cytoskeletal changes associated with differentiation in mouse astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of epithelial cell proliferation

ISS

1 reference

8 April 2019

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

type B pancreatic cell development

1 reference

8 April 2019

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of myeloid cell differentiation

1 reference

8 April 2019

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of cellular senescence

1 reference

8 April 2019

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of cell population proliferation

IMP

1 reference

8 April 2019

Beyond the cell cycle: a new role for Cdk6 in differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of monocyte differentiation

TAS

1 reference

8 April 2019

ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534

regulation of G2/M transition of mitotic cell cycle

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00534&geneProductId=UniProtKB:Q00534

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Beyond the cell cycle: a new role for Cdk6 in differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

TAS

protein phosphorylation

3 references

8 April 2019

8 April 2019

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

hematopoietic progenitor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

hematopoietic stem cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

regulation of hematopoietic stem cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

negative regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00534

physically interacts with

TAS

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7380

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3894860

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL189963

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301610

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL445813

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL488436

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545110

Gene Atlas image

PBB GE CDK6 207143 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q00534

1 reference

serine/threonine-protein kinase, active site

Identifiers.org

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016