(Q52081212)

21 April 2018

title

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. (English)

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21 April 2018

author name string

Fugmann SD

1

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21 April 2018

Villey IJ

2

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21 April 2018

Ptaszek LM

3

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21 April 2018

Schatz DG

4

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21 April 2018

publication date

1 January 2000

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21 April 2018

published in

Molecular Cell

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21 April 2018

volume

5

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21 April 2018

issue

1

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21 April 2018

page(s)

97-107

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21 April 2018

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

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All three residues of the Tn 10 transposase DDE catalytic triad function in divalent metal ion binding

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Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system

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Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

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The three chemical steps of Tn10/IS10 transposition involve repeated utilization of a single active site

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High-resolution structure of the catalytic domain of avian sarcoma virus integrase

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The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis

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The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

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Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

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Multiple DNA processing reactions underlie Tn7 transposition

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V(D)J recombination: a functional definition of the joining signals

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

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Rejoining of DNA by the RAG1 and RAG2 proteins

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7 January 2021

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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Formation and resolution of double-strand break intermediates in V(D)J rearrangement

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Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration

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A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

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Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition

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Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.

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PHD: predicting one-dimensional protein structure by profile-based neural networks

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7 January 2021

Definition of a core region of RAG-2 that is functional in V(D)J recombination

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7 January 2021

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

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7 January 2021

The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products.

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7 January 2021

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

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7 January 2021

The V(D)J recombination activating gene, RAG-1.

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RAG mutations in human B cell-negative SCID.

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

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7 January 2021

Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.

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The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

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7 January 2021

A general two-metal-ion mechanism for catalytic RNA

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7 January 2021

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

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7 January 2021

New insights into V(D)J recombination and its role in the evolution of the immune system

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

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7 January 2021

Stimulation of V(D)J cleavage by high mobility group proteins

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7 January 2021

Partial V(D)J recombination activity leads to Omenn syndrome

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7 January 2021

Organization and dynamics of the Mu transpososome: recombination by communication between two active sites

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7 January 2021

10.1016/S1097-2765(00)80406-2

Identifiers

DOI

1 reference

21 April 2018

1 reference

21 April 2018