(Q52531966)

2 May 2018

review article

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title

Mutagenic properties of topoisomerase-targeted drugs. (English)

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2 May 2018

author name string

B C Baguley

series ordinal

1

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2 May 2018

L R Ferguson

series ordinal

2

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2 May 2018

publication date

1 October 1998

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2 May 2018

Biochimica et Biophysica Acta

published in

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2 May 2018

volume

1400

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2 May 2018

page(s)

213-222

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2 May 2018

issue

1-3

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2 May 2018

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7 January 2021

Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.

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Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

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7 January 2021

Illegitimate recombination mediated by T4 DNA topoisomerase in vitro. Recombinants between phage and plasmid DNA molecules.

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7 January 2021

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

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7 January 2021

Topoisomerase II enzymes and mutagenicity

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7 January 2021

Role of nonhistone proteins in metaphase chromosome structure

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7 January 2021

Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma line

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7 January 2021

Mitotic chromosome condensation.

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7 January 2021

Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus

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7 January 2021

Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-MYC gene locus in living cells and in high-salt-extracted nuclei.

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7 January 2021

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

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7 January 2021

UVB-induced DNA breaks interfere with transcriptional induction of c-fos

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The 90 kDa heat shock protein (hsp90) induces the condensation of the chromatin structure.

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The effect of heat shock on the morphology of amphibian lampbrush chromosomes.

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7 January 2021

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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7 January 2021

Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells

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7 January 2021

Cellular responses to methyl-N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells

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7 January 2021

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells

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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

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7 January 2021

The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

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7 January 2021

Localization of DNA topoisomerase II in Chinese hamster fibroblasts by confocal and electron microscopy

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7 January 2021

A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase II cleavage at DNA sites distinct from those of amsacrine

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7 January 2021

Initiation of DNA replication in eukaryotic cells

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Genes occupy a fixed and symmetrical position on sister chromatids

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7 January 2021

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

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7 January 2021

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8

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7 January 2021

Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide

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7 January 2021

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death

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7 January 2021

Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia and Fanconi's anaemia cells.

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Different fates of camptothecin-induced replication fork-associated double-strand DNA breaks in mammalian cells

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7 January 2021

Sister-chromatid exchanges (SCE) induction by inhibitors of DNA topoisomerases in cultured human lymphocytes

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7 January 2021

Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase

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7 January 2021

Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis

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7 January 2021

Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26

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7 January 2021

DNA topoisomerase II is required for formation of mitotic chromosomes in Chinese hamster ovary cells: studies using the inhibitor 4'-demethylepipodophyllotoxin 9-(4,6-O-thenylidene-beta-D-glucopyranoside).

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DNA topoisomerase II is required at the time of mitosis in yeast

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Coming undone: how to untangle a chromosome

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7 January 2021

Scanning electron microscopy of mammalian chromosomes from prophase to telophase

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7 January 2021

Chromosome assembly in vitro: Topoisomerase II is required for condensation

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7 January 2021

Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment

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7 January 2021

The genetic control of meiosis

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The repair of double-strand breaks in DNA; a model involving recombination

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7 January 2021

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

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Meiosis-induced double-strand break sites determined by yeast chromatin structure

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7 January 2021

Meiosis-specific arrest revealed in DNA topoisomerase II mutants

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Molecular perspectives of chromosome pairing at meiosis

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Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast

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Anti-topoisomerase II recognizes meiotic chromosome cores

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Is the synaptonemal complex a disjunction machine?

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Sister-chromatid cohesion in mitosis and meiosis

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Mutagenicity of anticancer drugs in mammalian germ cells

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7 January 2021

Effects of etoposide on stage-specific DNA synthesis during rat spermatogenesis

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Analysis of micronuclei induced in mouse early spermatids by mitomycin C, vinblastine sulfate or etoposide using fluorescence in situ hybridization

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Fragmentation of centromeric DNA and prevention of homologous chromosome separation in male mouse meiosis in vivo by the topoisomerase II inhibitor etoposide

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Etoposide (VP-16) is a potent inducer of micronuclei in male rat meiosis: spermatid micronucleus test and DNA flow cytometry after etoposide treatment

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Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy

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Fertility, reproduction, and genetic disease: studies on the mutagenic effects of environmental agents on mammalian germ cells

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A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stems cells

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Female-specific mutagenic response of mice to hycanthone

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DNA topoisomerase II inhibition and gene amplification in V79/B7 cells.

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When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

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Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer

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Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation

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Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation

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Infant leukemia, topoisomerase II inhibitors, and the MLL gene

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Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.

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Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

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Inhibition of DNA Topoisomerases by Sanguiin H-6, a Cytotoxic Dimeric Ellagitannin fromSanguisorba officinalis1

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Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects

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7 January 2021

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Identifiers

DOI

1 reference

2 May 2018

PubMed ID

9748584

1 reference

2 May 2018