(Q53302291)

English

Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells.

scientific article published on 6 September 2010

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20818433%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20818433%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

ChEBI release 2020-05-28

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

F M Kaplan

1

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13 February 2020

Y Shao

2

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13 February 2020

M M Mayberry

3

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13 February 2020

A E Aplin

4

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13 February 2020

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publication date

6 September 2010

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13 February 2020

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13 February 2020

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13 February 2020

366-371

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13 February 2020

3

1 reference

Europe PubMed Central

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13 February 2020

https://scigraph.springernature.com/pub.10.1038/onc.2010.408

0 references

B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Mutant B-RAF mediates resistance to anoikis via Bad and Bim.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Mcl-1 is required for melanoma cell resistance to anoikis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Paradoxical activation of Raf by a novel Raf inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

B-RAF is a therapeutic target in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Targeting mutant BRAF and KIT in metastatic melanoma: ASCO 2009 meeting report.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.408

21 January 2018

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20818433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/20818433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melanoma cell lines from different stages of progression and their biological and molecular analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20818433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2010.408

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20818433%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20818433%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20818433%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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