(Q53348981)

13 May 2018

review article

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title

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. (English)

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13 May 2018

1

Christopher M Overall

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13 May 2018

author name string

Oded Kleifeld

series ordinal

2

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13 May 2018

language of work or name

English

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publication date

1 March 2006

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13 May 2018

published in

Nature Reviews Cancer

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13 May 2018

volume

6

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13 May 2018

issue

3

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13 May 2018

page(s)

227-239

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13 May 2018

Drug discovery: a historical perspective

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Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

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Tales from the crypt[ic] sites of the extracellular matrix

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Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression

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Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

31 March 2020

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Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

31 March 2020

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Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction

31 March 2020

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Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression

31 March 2020

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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

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A protective role for matrix metalloproteinase-3 in squamous cell carcinoma

31 March 2020

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Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance

31 March 2020

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MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

31 March 2020

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Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in c

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31 March 2020

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A multigenic program mediating breast cancer metastasis to bone

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Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

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The tumor microenvironment: CXCR4 is associated with distinct protein expression patterns in neuroblastoma cells

31 March 2020

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HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

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Progression of mouse mammary tumors: MCP-1-TNFalpha cross-regulatory pathway and clonal expression of promalignancy and antimalignancy factors

31 March 2020

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A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

31 March 2020

1 reference

Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front

31 March 2020

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Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells

31 March 2020

1 reference

Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice

31 March 2020

1 reference

Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils

31 March 2020

1 reference

Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3

31 March 2020

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Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma

31 March 2020

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Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

31 March 2020

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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

31 March 2020

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Mass spectrometry-based proteomics

31 March 2020

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

31 March 2020

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Activity-based probes for the proteomic profiling of metalloproteases

31 March 2020

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Examination of novel zinc-binding groups for use in matrix metalloproteinase inhibitors

31 March 2020

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Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11.

31 March 2020

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Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs

31 March 2020

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Conformational variability of matrix metalloproteinases: beyond a single 3D structure

31 March 2020

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Impact of mobility on structure-based drug design for the MMPs

31 March 2020

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Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.

31 March 2020

1 reference

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

31 March 2020

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31 March 2020

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Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry

31 March 2020

1 reference

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

31 March 2020

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Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1821

1 reference

13 May 2018

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13 May 2018