(Q53348981)

13 May 2018

review article

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title

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. (English)

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13 May 2018

1

Christopher M Overall

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13 May 2018

author name string

Oded Kleifeld

series ordinal

2

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13 May 2018

language of work or name

English

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publication date

1 March 2006

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13 May 2018

published in

Nature Reviews Cancer

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13 May 2018

volume

6

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13 May 2018

page(s)

227-239

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13 May 2018

issue

3

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/nrc1821

exact match

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cites work

Drug discovery: a historical perspective

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Protease degradomics: a new challenge for proteomics

31 March 2020

1 reference

Human and mouse proteases: a comparative genomic approach

31 March 2020

1 reference

Target identification and validation in drug discovery: the role of proteomics

31 March 2020

1 reference

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

31 March 2020

1 reference

Matrix metalloproteinases

31 March 2020

1 reference

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

Genes that mediate breast cancer metastasis to lung

31 March 2020

1 reference

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

31 March 2020

1 reference

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

31 March 2020

1 reference

Breast cancer metastasis: markers and models

31 March 2020

1 reference

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

31 March 2020

1 reference

Strategies for MMP inhibition in cancer: innovations for the post-trial era.

31 March 2020

1 reference

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

31 March 2020

1 reference

Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects

31 March 2020

1 reference

Matrix metalloproteinases: they're not just for matrix anymore!

31 March 2020

1 reference

Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats

31 March 2020

1 reference

Matrix metalloproteinases as modulators of inflammation and innate immunity

31 March 2020

1 reference

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

31 March 2020

1 reference

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

31 March 2020

1 reference

Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

31 March 2020

1 reference

The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies

31 March 2020

1 reference

Cancer and the chemokine network

31 March 2020

1 reference

A phase 2 study of bortezomib in relapsed, refractory myeloma

31 March 2020

1 reference

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

31 March 2020

1 reference

Failing the public health--rofecoxib, Merck, and the FDA.

31 March 2020

1 reference

COX-2 inhibitors--lessons in drug safety

31 March 2020

1 reference

Merck faces ongoing claims after Texan ruling on rofecoxib

31 March 2020

1 reference

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

31 March 2020

1 reference

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

31 March 2020

1 reference

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

31 March 2020

1 reference

Tales from the crypt[ic] sites of the extracellular matrix

31 March 2020

1 reference

Matrix metalloproteinases process the laminin-5 gamma 2-chain and regulate epithelial cell migration

31 March 2020

1 reference

Metalloproteinases and their inhibitors in tumor angiogenesis

31 March 2020

1 reference

Angiostatin induces and sustains dormancy of human primary tumors in mice

31 March 2020

1 reference

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

31 March 2020

1 reference

Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis

31 March 2020

1 reference

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

31 March 2020

1 reference

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

31 March 2020

1 reference

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases

31 March 2020

1 reference

Insulin-Like Growth Factor Binding Protein-5 Is a Target of Matrix Metalloproteinase-7: Implications for Epithelial-Mesenchymal Signaling

31 March 2020

1 reference

Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells

31 March 2020

1 reference

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

31 March 2020

1 reference

31 March 2020

Inflammation and cancer

1 reference

Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions

31 March 2020

1 reference

Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators

31 March 2020

1 reference

A system for stable expression of short interfering RNAs in mammalian cells

31 March 2020

1 reference

Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial

31 March 2020

1 reference

A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer

31 March 2020

1 reference

Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

1 reference

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer

31 March 2020

1 reference

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

31 March 2020

1 reference

Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice

31 March 2020

1 reference

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

31 March 2020

1 reference

Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression

31 March 2020

1 reference

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

31 March 2020

1 reference

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

31 March 2020

1 reference

Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction

31 March 2020

1 reference

Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression

31 March 2020

1 reference

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

31 March 2020

1 reference

A protective role for matrix metalloproteinase-3 in squamous cell carcinoma

31 March 2020

1 reference

Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: correlation with angiostatin generation and its clinical significance

31 March 2020

1 reference

Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance

31 March 2020

1 reference

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

31 March 2020

1 reference

Characterization of the distinct collagen binding, helicase and cleavage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the differential roles of the MMP hemopexin c domains and the MMP-2 fibronectin type II modules in c

31 March 2020

1 reference

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors

31 March 2020

1 reference

A multigenic program mediating breast cancer metastasis to bone

31 March 2020

1 reference

Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

The tumor microenvironment: CXCR4 is associated with distinct protein expression patterns in neuroblastoma cells.

31 March 2020

1 reference

HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

31 March 2020

1 reference

Progression of mouse mammary tumors: MCP-1-TNFalpha cross-regulatory pathway and clonal expression of promalignancy and antimalignancy factors

31 March 2020

1 reference

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

31 March 2020

1 reference

Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front

31 March 2020

1 reference

Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells

31 March 2020

1 reference

Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice

31 March 2020

1 reference

Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils

31 March 2020

1 reference

Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3

31 March 2020

1 reference

Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma

31 March 2020

1 reference

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

31 March 2020

1 reference

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

31 March 2020

1 reference

Mass spectrometry-based proteomics

31 March 2020

1 reference

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

31 March 2020

1 reference

Activity-based probes for the proteomic profiling of metalloproteases

31 March 2020

1 reference

Examination of novel zinc-binding groups for use in matrix metalloproteinase inhibitors

31 March 2020

1 reference

Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11.

31 March 2020

1 reference

Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs

31 March 2020

1 reference

Conformational variability of matrix metalloproteinases: beyond a single 3D structure

31 March 2020

1 reference

Impact of mobility on structure-based drug design for the MMPs

31 March 2020

1 reference

Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.

31 March 2020

1 reference

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

31 March 2020

1 reference

31 March 2020

1 reference

Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry

31 March 2020

1 reference

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

31 March 2020

1 reference

Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1821

1 reference

13 May 2018

PubMed ID

16498445

1 reference

13 May 2018