(Q53405286)

14 May 2018

title

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. (English)

1 reference

14 May 2018

author name string

Tse KF

series ordinal

1

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14 May 2018

Mukherjee G

series ordinal

2

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14 May 2018

Small D

series ordinal

3

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14 May 2018

publication date

1 October 2000

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14 May 2018

published in

Leukemia

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14 May 2018

volume

14

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14 May 2018

page(s)

1766-1776

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14 May 2018

issue

10

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14 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.leu.2401905

exact match

0 references

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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

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Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

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FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

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Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

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p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

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Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

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A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

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7 January 2021

The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

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7 January 2021

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7 January 2021

The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

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7 January 2021

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

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Identifiers

DOI

10.1038/SJ.LEU.2401905

1 reference

14 May 2018

release_geoq72fvp5grrlg2tbdo3olwqi

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/geoq72fvp5grrlg2tbdo3olwqi

24 November 2022

mapped directly with Wikidata item

PubMed ID

11021752

1 reference

14 May 2018