(Q53412655)

14 May 2018

title

The paradox of E2F1: oncogene and tumor suppressor gene. (English)

1 reference

14 May 2018

author name string

Johnson DG

series ordinal

1

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14 May 2018

publication date

1 March 2000

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14 May 2018

published in

Molecular Carcinogenesis

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14 May 2018

volume

27

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14 May 2018

page(s)

151-157

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14 May 2018

issue

3

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14 May 2018

Mutation and cancer: statistical study of retinoblastoma

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The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter

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A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

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The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

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Differential activities of E2F family members: unique functions in regulating transcription

21 January 2018

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Rb interacts with histone deacetylase to repress transcription

21 January 2018

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The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

21 January 2018

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The E2F transcription factor is a cellular target for the RB protein

21 January 2018

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

21 January 2018

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

21 January 2018

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

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Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

21 January 2018

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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

21 January 2018

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Distinct roles for E2F proteins in cell growth control and apoptosis

21 January 2018

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p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

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E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

21 January 2018

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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Multiple members of the E2F transcription factor family are the products of oncogenes

21 January 2018

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E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo

21 January 2018

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E2F-4, a new member of the E2F transcription factor family, interacts with p107

21 January 2018

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Effects of an Rb mutation in the mouse

21 January 2018

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E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes

21 January 2018

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E2F-1-induced p53-independent apoptosis in transgenic mice.

21 January 2018

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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

21 January 2018

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E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

21 January 2018

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

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Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes

21 January 2018

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Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products

21 January 2018

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Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis

21 January 2018

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Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

21 January 2018

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Retinoblastoma protein switches the E2F site from positive to negative element

21 January 2018

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E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

21 January 2018

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

21 January 2018

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21 January 2018

Oncogenes and cell death

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

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21 January 2018

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21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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Rapid analysis of gene expression (RAGE) facilitates universal expression profiling

21 January 2018

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

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21 January 2018

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

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21 January 2018

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

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BRCA1 regulates p53-dependent gene expression

21 January 2018

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21 January 2018

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Transcriptional activation by BRCA1

21 January 2018

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10.1002/(SICI)1098-2744(200003)27:3<151::AID-MC1>3.0.CO;2-C

21 January 2018

Identifiers

DOI

1 reference

14 May 2018

PubMed ID

10708476

1 reference

14 May 2018