(Q53961769)

23 May 2018

title

Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. (English)

1 reference

23 May 2018

non-small-cell lung carcinoma

main subject

apoptotic process

0 references

1 reference

J Brognard

1

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23 May 2018

P A Dennis

series ordinal

2

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23 May 2018

publication date

1 September 2002

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23 May 2018

Cell Death & Differentiation

published in

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23 May 2018

volume

9

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23 May 2018

page(s)

893-904

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23 May 2018

issue

9

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23 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401054

exact match

0 references

1 reference

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Cancer statistics, 1999.

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

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Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.

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Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

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Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells.

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Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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Cell culture methods for the establishment of the NCI series of lung cancer cell lines.

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Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arrest and apoptosis in tumor cells in which the pathway is constitutively activated: up-regulation of p27(Kip1)

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MEK inhibition enhances paclitaxel-induced tumor apoptosis

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Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

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PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase

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Identifiers

DOI

10.1038/SJ.CDD.4401054

1 reference

23 May 2018

PubMed ID

12181740

1 reference

23 May 2018