(Q54114456)

English

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

scientific article published in December 1998

In more languages

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scholarly article

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase. (English)

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

author name string

L Yu

1

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

L Orlandi

2

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

P Wang

3

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

M S Orr

4

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

A M Senderowicz

5

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

E A Sausville

6

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

R Silvestrini

7

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

N Watanabe

8

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

H Piwnica-Worms

9

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

P M O'Connor

10

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

language of work or name

0 references

publication date

1 December 1998

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

Journal of Biological Chemistry

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

273

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

33455-33464

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

50

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The cdc25 protein contains an intrinsic phosphatase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The cdc25 M-phase inducer: an unconventional protein phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Evidence for a NIMA-like mitotic pathway in vertebrate cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Checkpoint pathways come of age.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.50.33455

21 January 2018

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.571

Identifiers

10.1074/JBC.273.50.33455

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

1 reference

Europe PubMed Central

24 May 2018

http://europepmc.org/abstract/MED/9837924

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