(Q54153135)

16 June 2018

review article

1 reference

title

Novel drug development opportunities for heparin. (English)

1 reference

16 June 2018

author name string

Rebecca Lever

series ordinal

1

1 reference

16 June 2018

Clive P Page

series ordinal

2

1 reference

16 June 2018

publication date

1 February 2002

1 reference

16 June 2018

Nature Reviews Drug Discovery

published in

1 reference

16 June 2018

volume

1

1 reference

16 June 2018

page(s)

140-148

1 reference

16 June 2018

issue

2

1 reference

16 June 2018

https://scigraph.springernature.com/pub.10.1038/nrd724

exact match

0 references

cites work

Heparan sulfate: decoding a dynamic multifunctional cell regulator

1 reference

Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis

31 March 2020

1 reference

Heparin in inflammation: potential therapeutic applications beyond anticoagulation.

31 March 2020

1 reference

Tissue factor pathway inhibitor and the revised theory of coagulation

31 March 2020

1 reference

The current status of coagulation

31 March 2020

1 reference

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

31 March 2020

1 reference

Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin

31 March 2020

1 reference

Further characterization of the antithrombin-binding sequence in heparin

31 March 2020

1 reference

Platelets: an update on diagnosis and management of thrombocytopenic disorders.

31 March 2020

1 reference

Synthesis of thrombin-inhibiting heparin mimetics without side effects

31 March 2020

1 reference

Design and synthesis of a novel synthetic NAPAP-penta-saccharide conjugate displaying a dual antithrombotic action.

31 March 2020

1 reference

Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans

31 March 2020

1 reference

One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by beta 2-agonists

31 March 2020

1 reference

Anticoagulant Action of Heparin

31 March 2020

1 reference

The observation of heparin on endothelium after injection

31 March 2020

1 reference

Heparin releases heparan sulfate from the cell surface

31 March 2020

1 reference

The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endothelium in vitro.

31 March 2020

1 reference

Bladder-Surface Glycosaminoglycans: An Efficient Mechanism of Environmental Adaptation

31 March 2020

1 reference

Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents

31 March 2020

1 reference

Monocyte adhesion to activated aortic endothelium: role of L-selectin and heparan sulfate proteoglycans

31 March 2020

1 reference

Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).

31 March 2020

1 reference

Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism

31 March 2020

1 reference

Effects of heparin and its desulfated derivatives on leukocyte-endothelial adhesion

31 March 2020

1 reference

The effects of heparin on the adhesion of human peripheral blood mononuclear cells to human stimulated umbilical vein endothelial cells.

31 March 2020

1 reference

Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant-induced firm adhesion in rat mesenteric venules in vivo

31 March 2020

1 reference

The effect of inhaled heparin and related glycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs

31 March 2020

1 reference

Heparin inhibits allergen-induced eosinophil infiltration into guinea-pig lung via a mechanism unrelated to its anticoagulant activity.

31 March 2020

1 reference

Effect of heparin and a low-molecular weight heparinoid on PAF-induced airway responses in neonatally immunized rabbits

31 March 2020

1 reference

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea-pig skin

31 March 2020

1 reference

Inhibition of delayed-type hypersensitivity by heparin depleted of anticoagulant activity

31 March 2020

1 reference

Optimal timing of hemodilution for brain protection in a canine model of focal cerebral ischemia

31 March 2020

1 reference

Heparin prevents antigen-induced airway hyperresponsiveness: interference with IP3-mediated mast cell degranulation?

31 March 2020

1 reference

Inhibition of antigen-induced acute bronchoconstriction, airway hyperresponsiveness, and mast cell degranulation by a nonanticoagulant heparin: comparison with a low molecular weight heparin.

31 March 2020

1 reference

Effect of heparin on antigen-induced airway responses and pulmonary leukocyte accumulation in neonatally immunized rabbits.

31 March 2020

1 reference

Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma

31 March 2020

1 reference

Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin

31 March 2020

1 reference

Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects

31 March 2020

1 reference

Lung deposition and clearance of inhaled (99m)Tc-heparin in healthy volunteers

31 March 2020

1 reference

Rheumatoid arthritis and heparin

31 March 2020

1 reference

Response to heparin in patients with ulcerative colitis

31 March 2020

1 reference

Treatment of corticosteroid-resistant ulcerative colitis with heparin--a report of 16 cases.

31 March 2020

1 reference

Intranasal heparin reduces eosinophil recruitment after nasal allergen challenge in patients with allergic rhinitis

31 March 2020

1 reference

Heparanases and tumor metastasis

31 March 2020

1 reference

Low-molecular-weight heparin and cancer

31 March 2020

1 reference

Actions of heparin that may affect the malignant process

31 March 2020

1 reference

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

31 March 2020

1 reference

Comparative analysis of the ability of leucocytes, endothelial cells and platelets to degrade the subendothelial basement membrane: evidence for cytokine dependence and detection of a novel sulfatase

31 March 2020

1 reference

Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins

31 March 2020

1 reference

Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity

31 March 2020

1 reference

Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis

31 March 2020

1 reference

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

31 March 2020

1 reference

Heparin is essential for the storage of specific granule proteases in mast cells

31 March 2020

1 reference

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

31 March 2020

1 reference

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

31 March 2020

1 reference

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

31 March 2020

1 reference

Cloning and functional expression of a human heparanase gene

31 March 2020

1 reference

Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer

31 March 2020

1 reference

Identification of active-site residues of the pro-metastatic endoglycosidase heparanase

31 March 2020

1 reference

Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member

31 March 2020

1 reference

Disruption of sulphated glycosaminoglycans in intestinal inflammation

31 March 2020

1 reference

Urinary glycosaminoglycan levels are increased in acute severe asthma--a role for eosinophil-derived gelatinase B?

31 March 2020

1 reference

The separation of active and inactive forms of heparin

31 March 2020

1 reference

Characterization of a phosphorylated pentasaccharide isolated from Hansenula holstii NRRL Y-2448 phosphomannan

31 March 2020

1 reference

Substrate specificity of heparanases from human hepatoma and platelets

31 March 2020

1 reference

Soluble complexes of regulated upon activation, normal T cells expressed and secreted (RANTES) and glycosaminoglycans suppress HIV-1 infection but do not induce Ca(2+) signaling

31 March 2020

1 reference

Antithrombotic activity of oral unfractionated heparin

31 March 2020

1 reference

A 3.0-kDa low molecular weight heparin promotes gastric ulcer healing in rats

31 March 2020

1 reference

Oral administration of low molecular weight heparin fractions in rabbits.

31 March 2020

1 reference

Investigations on plasma activity of low molecular weight heparin after intravenous and oral administrations

31 March 2020

1 reference

Human pharmacokinetics of glycosaminoglycans using deuterium-labeled and unlabeled substances: evidence for oral absorption

31 March 2020

1 reference

Oral drug absorption enhancement by chitosan and its derivatives

31 March 2020

1 reference

Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent

31 March 2020

1 reference

Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis

31 March 2020

1 reference

Single amino acid residues in the E- and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity

31 March 2020

1 reference

Oligosaccharides corresponding to the regular sequence of heparin: chemical synthesis and interaction with FGF-2.

31 March 2020

1 reference

Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis

31 March 2020

1 reference

Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma

31 March 2020

1 reference

Epithelial coating techniques in the treatment of interstitial cystitis

31 March 2020

1 reference

Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading

31 March 2020

1 reference

Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells

31 March 2020

1 reference

A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement

31 March 2020

1 reference

Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD724

1 reference

16 June 2018

Dimensions Publication ID

0 references

1 reference

16 June 2018