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Sodium channels as molecular targets for antiepileptic drugs
scientific article published on 01 March 1998
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Sodium channels as molecular targets for antiepileptic drugs
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
author name string
D S Ragsdale
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
M Avoli
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
language of work or name
English
0 references
publication date
1 March 1998
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
volume
26
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
page(s)
16-28
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
cites work
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Currents related to movement of the gating particles of the sodium channels
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Destruction of sodium conductance inactivation in squid axons perfused with pronase
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7 January 2021
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Charge movement associated with the opening and closing of the activation gates of the Na channels
1 reference
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Crossref
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7 January 2021
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A rat brain Na+ channel alpha subunit with novel gating properties
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7 January 2021
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Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.
1 reference
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On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain
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Sodium channel mRNAs I, II and III in the CNS: cell-specific expression.
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Regional and temporal expression of sodium channel messenger RNAs in the rat brain during development
1 reference
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Crossref
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7 January 2021
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Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’
1 reference
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Crossref
reference URL
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7 January 2021
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Cellular and molecular biology of voltage-gated sodium channels
1 reference
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Crossref
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7 January 2021
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Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones.
1 reference
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7 January 2021
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An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
1 reference
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7 January 2021
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Persistent sodium current in mammalian central neurons
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7 January 2021
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Anticonvulsant activity of topiramate and phenytoin in a rat model of ischemia-induced epilepsy
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7 January 2021
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Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.
1 reference
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7 January 2021
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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?
1 reference
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Crossref
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7 January 2021
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Tissue-specific expression of the RI and RII sodium channel subtypes
1 reference
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7 January 2021
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Molecular model of the action potential sodium channel
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7 January 2021
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Calcium channel characteristics conferred on the sodium channel by single mutations
1 reference
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7 January 2021
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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction
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7 January 2021
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inferred from DOI database lookup
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
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7 January 2021
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The components of membrane conductance in the giant axon of Loligo
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7 January 2021
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The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
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A quantitative description of membrane current and its application to conduction and excitation in nerve
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7 January 2021
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Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
1 reference
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7 January 2021
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Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel
1 reference
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Auxiliary subunits of voltage-gated ion channels
1 reference
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7 January 2021
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Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif
1 reference
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7 January 2021
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Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line
1 reference
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Crossref
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7 January 2021
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Na+ channel subunits and Ig domains
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Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes
1 reference
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7 January 2021
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Structure, function and expression of voltage-dependent sodium channels
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Primary structure of rat brain sodium channel III deduced from the cDNA sequence
1 reference
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Crossref
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7 January 2021
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Role of inactivation in local anesthetic action
1 reference
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Crossref
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7 January 2021
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Inactivation of cloned Na channels expressed in Xenopus oocytes
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Na+ channels must deactivate to recover from inactivation
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Carbamazepine inhibition of neuronal Na+ currents: quantitative distinction from phenytoin and possible therapeutic implications
1 reference
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Crossref
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7 January 2021
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Transmembrane movement of the shaker K+ channel S4.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
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Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex
1 reference
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7 January 2021
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Localization of a human brain sodium channel gene (SCN2A) to chromosome 2
1 reference
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7 January 2021
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Pore loops: an emerging theme in ion channel structure
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Three brain sodium channel α-subunit genes are clustered on the proximal segment of mouse chromosome 2
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of a putative human brain sodium channel gene (SCN1A) to chromosome band 2q24
1 reference
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Crossref
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7 January 2021
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Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31
1 reference
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Crossref
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7 January 2021
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Specific and potent interactions of carbamazepine with brain adenosine receptors
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice
1 reference
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7 January 2021
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Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
1 reference
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reference URL
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7 January 2021
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Existence of distinct sodium channel messenger RNAs in rat brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
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inferred from DOI database lookup
Expression of functional sodium channels from cloned cDNA.
1 reference
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Crossref
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7 January 2021
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The epileptogenic effects of folate derivatives in the rat.
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7 January 2021
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Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of Carbamazepine on the In Vitro Uptake and Release of Norepinephrine in Adrenergic Nerves of Rabbit Aorta and in Whole Brain Synaptosomes
1 reference
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7 January 2021
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Molecular determinants of state-dependent block of Na+ channels by local anesthetics
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
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Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis of ion channel permeation and selectivity
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A novel, abundant sodium channel expressed in neurons and glia
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenytoin and carbamazepine: potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
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Topiramate: preclinical evaluation of structurally novel anticonvulsant.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 1. Neurochemical Studies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural parts involved in activation and inactivation of the sodium channel
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Double-blind, placebo-controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
μl Na+ channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of an intracellular peptide segment involved in sodium channel inactivation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topiramate: a potent anticonvulsant in the amygdala-kindled rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient expression of rat brain type IIA Na+ channel α subunits in a somatic cell line
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
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Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
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Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
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inferred from DOI database lookup
Molecular basis of charge movement in voltage-gated sodium channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
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Lamotrigine: a review of antiepileptic efficacy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
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Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
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7 January 2021
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A single linkage group comprising 11 polymorphic DNA markers on rat Chromosome 3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
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Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-0173%2897%2900054-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-0173(97)00054-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
PubMed publication ID
9600622
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9600622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9600622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 November 2019
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