(Q57150265)

English

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

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scholarly article

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Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump (English)

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author name string

Michael D Aleo

1

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Yi Luo

2

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Rachel Swiss

3

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Paul D Bonin

4

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David M Potter

5

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Yvonne Will

6

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language of work or name

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publication date

September 2014

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60

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1015-22

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3

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Epidemiology of idiosyncratic drug-induced liver injury

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Liver transplantation for acute liver failure from drug induced liver injury in the United States

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Risk factors for idiosyncratic drug-induced liver injury

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Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

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Concordance of the toxicity of pharmaceuticals in humans and in animals

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Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan

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What is idiosyncratic hepatotoxicity? What is it not?

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Idiosyncratic toxicity: a convergence of risk factors

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Genetic and molecular factors in drug-induced liver injury: a review.

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Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

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Pharmacogenetics of drug-induced liver injury

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High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

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Managing the challenge of chemically reactive metabolites in drug development.

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Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose

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Membrane transporters in drug development

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Bile acid transporters: structure, function, regulation and pathophysiological implications

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The bile salt export pump

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Bile salt excretory pump: biology and pathobiology

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Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

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Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone

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Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.

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Cyclosporin A and cholestasis: Its mechanism(s) and clinical relevancy.

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Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

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Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

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Mitochondrial involvement in drug-induced hepatic injury

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The significance of mitochondrial toxicity testing in drug development

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Correlation between cellular ATP level and bile excretion in the rat liver

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Liver adenosine triphosphate content and bile flow rate in the rat.

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Relation of biliary bile acid output to hepatic adenosine triphosphate level and biliary indocyanine green excretion in humans

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Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy

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Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes.

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In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

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Mechanisms of benzarone and benzbromarone-induced hepatic toxicity

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Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

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Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs

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FDA-approved drug labeling for the study of drug-induced liver injury

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High-throughput analysis of mitochondrial oxygen consumption

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Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes

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A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

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Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.

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In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

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Mitochondrial involvement in drug-induced liver injury.

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Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

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Identifiers

10.1002/HEP.27206

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