(Q57222163)

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CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

scientific article published on 17 October 2011

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scholarly article

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14 January 2020

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells (English)

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14 January 2020

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Sonia Fernandez

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Reena Rajasuriar

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Michael R Beard

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Anthony W. Purcell

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Sharon R. Lewin

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Martyn A. French

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Sara Tanaskovic

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Marit Kramski

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Patricia Price

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17 October 2011

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14 January 2020

Journal of Infectious Diseases

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1927-1935

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14 January 2020

The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Clinical outcome of HIV-infected patients with discordant virological and immunological response to antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Incidence of non-AIDS-defining malignancies in HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Immunodeficiency and renal impairment are risk factors for HIV-associated acute renal failure

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Impaired induction of CD27 and CD28 predicts naive CD4 T cell proliferation defects in HIV disease

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

HIV disease: fallout from a mucosal catastrophe?

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic interferon response as well as extensive transcriptional changes in CD8+ T c

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

TLR Ligand-Induced Type I IFNs Affect Thymopoiesis.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Stimulated plasmacytoid dendritic cells impair human T-cell development

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Novel sensitive real-time PCR for quantification of bacterial 16S rRNA genes in plasma of HIV-infected patients as a marker for microbial translocation

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Evolution of CD4+ T cell count in HIV-1-infected adults receiving antiretroviral therapy with sustained long-term virological suppression

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Reduction of immune activation with chloroquine therapy during chronic HIV infection

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recovery in Virologically Suppressed HIV‐Infected Patients: Clinical Implications

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR659

21 January 2018

Identifiers

10.1093/INFDIS/JIR659

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Europe PubMed Central

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14 January 2020

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Europe PubMed Central

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14 January 2020

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