(Q57245132)

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Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica

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Stabilization Effect of Resin on the Production of Potent Proteasome Inhibitor NPI-0052 During Submerged Fermentation of Salinispora tropica (English)

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Salinispora tropica

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Salinispora tropica

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Ginger Tsueng

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Kin S Lam

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publication date

July 2007

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number of pages

4

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The Journal of Antibiotics

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60

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7

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469-472

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

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A novel proteasome inhibitor NPI-0052 as an anticancer therapy

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Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

1 reference

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Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

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NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.

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Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

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A mechanistic and kinetic study of the beta-lactone hydrolysis of Salinosporamide A (NPI-0052), a novel proteasome inhibitor.

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The effect of cerulenin on the production of esperamicin A1 by Actinomadura verrucosospora

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Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis

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Characterization of product capture resin during microbial cultivations.

1 reference

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Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome

1 reference

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10.1038/JA.2007.61

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