(Q58483575)

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The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria

scientific article published on 27 April 2006

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scholarly article

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20 January 2020

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria (English)

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20 January 2020

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molecular biology

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structural biology

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protein structure

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Marco Bellinzoni

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Pedro M. Alzari

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Annemarie Wehenkel

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Annemarie Wehenkel

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Pablo Fernandez

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Vincent Catherinot

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Nathalie Barilone

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27 April 2006

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3018-3022

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Signaling--2000 and beyond

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21 January 2018

Genes required for mycobacterial growth defined by high density mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis

1 reference

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21 January 2018

Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

1 reference

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21 January 2018

Protein kinases--the major drug targets of the twenty-first century?

1 reference

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21 January 2018

Protein kinase inhibitors: insights into drug design from structure.

1 reference

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21 January 2018

Placement of medium-sized molecular fragments into active sites of proteins.

1 reference

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21 January 2018

Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method

1 reference

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21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Likelihood-enhanced fast translation functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2006.04.046

21 January 2018

Identifiers

10.1016/J.FEBSLET.2006.04.046

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16674948%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

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20 January 2020

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