(Q5918988)

English

Interferon lambda 1

mammalian protein found in Homo sapiens

cytokine Zcyto21
IFNL1
IL-29
interferon lambda-1
interleukin 29 (interferon, lambda 1)
interleukin-29
IFN-lambda-1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Interferon lambda

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU54

Interferon lambda superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IU54

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

interleukin-28 receptor binding

determination method

1 reference

8 April 2019

IL-28, IL-29 and their class II cytokine receptor IL-28R

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

signaling receptor binding

determination method

1 reference

31 January 2018

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU54&geneProductId=UniProtKB:Q8IU54

determination method

interleukin-28 receptor complex

determination method

1 reference

8 April 2019

IL-28, IL-29 and their class II cytokine receptor IL-28R

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU54&geneProductId=UniProtKB:Q8IU54

determination method

extracellular region

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

8 April 2019

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

biological process

receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of interleukin-5 production

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

8 April 2019

Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

positive regulation of interferon-gamma production

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of interleukin-13 production

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

defense response to virus

determination method

3 references

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU54&geneProductId=UniProtKB:Q8IU54

determination method

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU54&geneProductId=UniProtKB:Q8IU54

determination method

31 January 2018

IL-28, IL-29 and their class II cytokine receptor IL-28R

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU54&geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of type 2 immune response

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

innate immune response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

positive regulation of MHC class I biosynthetic process

determination method

1 reference

8 April 2019

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of memory T cell differentiation

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of T cell differentiation

determination method

1 reference

8 April 2019

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

negative regulation of cell population proliferation

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

defense response to virus

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

8 April 2019

IL-28, IL-29 and their class II cytokine receptor IL-28R

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU54

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000329991

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000329991

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Multilingual sites(0 entries)

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