(Q61842774)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

review article

1 reference

title

Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

0 references

1 reference

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

I L Williams

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

S B Wheatcroft

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

M T Kearney

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

language of work or name

English

0 references

publication date

1 June 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Obesity

9 November 2019

published in

0 references

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

page(s)

754-764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12037644%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.ijo.0801995

9 November 2019

exact match

0 references

cites work

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Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland

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A prospective study of obesity and risk of coronary heart disease in women

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7 January 2021

Body Weight and Mortality among Women

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7 January 2021

Weight, weight change, and coronary heart disease in women. Risk within the 'normal' weight range.

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7 January 2021

Science, medicine, and the future. Obesity treatment

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7 January 2021

Atherosclerosis — An Inflammatory Disease

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7 January 2021

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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7 January 2021

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein

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7 January 2021

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase

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7 January 2021

Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells

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7 January 2021

Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine

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7 January 2021

Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells

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7 January 2021

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

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7 January 2021

Effect of exercise on coronary endothelial function in patients with coronary artery disease.

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7 January 2021

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

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7 January 2021

Expression and regulation of endothelial nitric oxide synthase

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7 January 2021

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

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7 January 2021

The endothelial nitric-oxide synthase-caveolin regulatory cycle

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7 January 2021

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells

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7 January 2021

Signal transduction of eNOS activation

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7 January 2021

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

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7 January 2021

Regulation and functional consequences of endothelial nitric oxide formation

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7 January 2021

Receptor-regulated translocation of endothelial nitric-oxide synthase

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7 January 2021

Nitric oxide synthases: which, where, how, and why?

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7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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7 January 2021

Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells

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7 January 2021

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

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7 January 2021

Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

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7 January 2021

AMP-activated protein kinase phosphorylation of endothelial NO synthase

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7 January 2021

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

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7 January 2021

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

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7 January 2021

Vascular dysfunction and myocardial contractility in the JCR:LA-corpulent rat.

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7 January 2021

Insulin signaling in the arterial wall

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7 January 2021

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

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7 January 2021

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

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7 January 2021

Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM.

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7 January 2021

Nitric oxide release accounts for insulin's vascular effects in humans

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7 January 2021

Effect of a Physiological Insulin Infusion on the Cardiovascular Responses to a High Fat Meal: Evidence Supporting a Role for Insulin in Modulating Postprandial Cardiovascular Homoeostasis in Man

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7 January 2021

Depressor action of insulin on skeletal muscle vasculature: a novel mechanism for postprandial hypotension in the elderly.

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7 January 2021

Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity

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7 January 2021

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

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7 January 2021

Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology

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7 January 2021

Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

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7 January 2021

Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm

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7 January 2021

Insulin and insulin-like growth factor-I cause coronary vasorelaxation in vitro

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7 January 2021

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

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7 January 2021

Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity

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7 January 2021

The L-arginine-nitric oxide pathway

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7 January 2021

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

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7 January 2021

Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine

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7 January 2021

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits

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7 January 2021

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

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7 January 2021

Arginine: a new therapy for atherosclerosis?

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7 January 2021

Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B.

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7 January 2021

Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells

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7 January 2021

Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation

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7 January 2021

Nitric oxide and coronary endothelial dysfunction in humans

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7 January 2021

Cellular and molecular mechanisms of endothelial cell dysfunction

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7 January 2021

Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences

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7 January 2021

Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo

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7 January 2021

Endothelial Gi protein in human coronary arteries

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein

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7 January 2021

Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein

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7 January 2021

Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic Rabbits

1 reference

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7 January 2021

Does ADMA cause endothelial dysfunction?

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia

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7 January 2021

Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats

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7 January 2021

Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin

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7 January 2021

Vascular oxidant stress: molecular mechanisms and pathophysiological implications

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7 January 2021

Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.

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7 January 2021

Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure

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7 January 2021

Effects of nitric oxide and superoxide on relaxation in human artery and vein

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7 January 2021

Nitric oxide regulation of free radical- and enzyme-mediated lipid and lipoprotein oxidation

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7 January 2021

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

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7 January 2021

Antioxidants, diabetes and endothelial dysfunction

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7 January 2021

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

1 reference

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7 January 2021

Expression of NADH/NADPH oxidase p22phox in human coronary arteries

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7 January 2021

A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis.

1 reference

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7 January 2021

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats

1 reference

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7 January 2021

NAD(P)H oxidase: role in cardiovascular biology and disease

1 reference

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7 January 2021

Interactions among ACE, kinins and NO.

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7 January 2021

Nitric oxide and the renin-angiotensin system. Is there a physiological interplay between the systems?

1 reference

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7 January 2021

Modulation of angiotensin-converting enzyme by nitric oxide

1 reference

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7 January 2021

Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats

1 reference

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7 January 2021

Science, medicine, and the future. Non-insulin dependent diabetes mellitus: the gathering storm

1 reference

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7 January 2021

Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study

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7 January 2021

Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators.

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7 January 2021

Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

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7 January 2021

Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity

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7 January 2021

Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance

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7 January 2021

Endothelial nitric oxide production and insulin sensitivity. A physiological link with implications for pathogenesis of cardiovascular disease

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7 January 2021

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

1 reference

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7 January 2021

Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity

1 reference

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7 January 2021

Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone.

1 reference

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7 January 2021

Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity.

1 reference

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7 January 2021

Influence of body fat distribution on free fatty acid metabolism in obesity

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7 January 2021

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

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7 January 2021

Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease

1 reference

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7 January 2021

Plasma free fatty acids and endothelium-dependent vasodilation: effect of chain-length and cyclooxygenase inhibition

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7 January 2021

Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: reversal after lipid-lowering therapy by atorvastatin

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7 January 2021

Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism

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https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Reactive oxygen species are critical in the oleic acid-mediated mitogenic signaling pathway in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

1 reference

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7 January 2021

Elevated serum TNF-alpha level as a link between endothelial dysfunction and insulin resistance in normotensive obese patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Leptin, the product of Ob gene, promotes angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Leptin induces oxidative stress in human endothelial cells.

1 reference

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7 January 2021

Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Leptin induces direct vasodilation through distinct endothelial mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Lipoprotein distribution and composition in obesity: their association with central adiposity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Troglitazone decreases the proportion of small, dense LDL and increases the resistance of LDL to oxidation in obese subjects.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Inhibitory effects of low-density lipoproteins from men with type II diabetes on endothelium-dependent relaxation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production : key role of L-arginine availability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Relationship of low-density lipoprotein particle size and measures of adiposity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Physical activity, obesity and blood lipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Effects of diet and serotonergic agonist on hepatic apolipoprotein B-100 secretion and endothelial function in obese men.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Gene expression of angiotensinogen in adipose tissue of obese patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Insulin-resistant lipolysis in abdominally obese hypertensive individuals. Role of the renin-angiotensin system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

The potential use of angiotensin-converting enzyme inhibitors in patients with hyperlipidemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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7 January 2021

Metformin improves vascular function in insulin-resistant rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Thiazolidinediones: a new class of antidiabetic drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Beyond lipids - the role of the endothelium in coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Mechanisms of oxidation, antioxidants, and atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Clinical importance of coronary endothelial vasodilator dysfunction and therapeutic options

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021

The oxidative paradox: another piece in the puzzle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0801995

7 January 2021