(Q64025565)

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SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

scientific article published on 01 March 2019

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scholarly article

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27 April 2020

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology (English)

1 reference

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27 April 2020

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

1 reference

GOA release 2020-03-11

Sortilin-related VPS10 domain containing receptor 2

1 reference

GOA release 2020-03-11

10

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27 April 2020

1

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27 April 2020

Kinga Szydlowska

2

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27 April 2020

7

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27 April 2020

Katarzyna Łukasiuk

11

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27 April 2020

author name string

Karolina Nizinska

3

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27 April 2020

Antonino Asaro

4

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27 April 2020

Erwin A van Vliet

5

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27 April 2020

Oliver Popp

6

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27 April 2020

Raphaela Fritsche-Guenther

8

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27 April 2020

Jennifer A Kirwan

9

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27 April 2020

Thomas E Willnow

13

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27 April 2020

Eleonora Aronica

12

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27 April 2020

publication date

1 March 2019

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27 April 2020

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27 April 2020

26

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27 April 2020

2792-2804.e6

1 reference

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27 April 2020

10

1 reference

Europe PubMed Central

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27 April 2020

Kindling and its consequences on learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C signaling and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The three sorCS genes are differentially expressed and regulated by synaptic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid trafficking of the neuronal glutamate transporter, EAAC1: evidence for distinct trafficking pathways differentially regulated by protein kinase C and platelet-derived growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress markers in surgically treated patients with refractory epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant role of GTRAP3-18 in neuronal glutathione synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VPS10P-domain receptors - regulators of neuronal viability and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress in epileptic seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane trafficking in neuronal maintenance and degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of subfield pathology in hippocampal sclerosis: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p75NTR, but not proNGF, is upregulated following status epilepticus in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidants as a preventive treatment for epileptic process: a review of the current status

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30840898

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CELREP.2019.02.027

1 reference

Europe PubMed Central

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27 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30840898%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30840898%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

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