(Q64226431)

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Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives

scientific article published on 12 February 2019

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Europe PubMed Central

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28 April 2020

Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives (English)

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28 April 2020

tumor progression

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hepatocellular carcinoma

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Sabrina Bimonte

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28 April 2020

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28 April 2020

Mauro Piccirillo

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Mauro Piccirillo

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28 April 2020

Raffaele Palaia

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Raffaele Palaia

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28 April 2020

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Vittorio Albino

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28 April 2020

Aurelio Nasto

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28 April 2020

Carlo Molino

5

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28 April 2020

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12 February 2019

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28 April 2020

Drug Design, Development and Therapy

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28 April 2020

13

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28 April 2020

611-621

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28 April 2020

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Creative Commons Attribution-NonCommercial 3.0 Unported

1 February 2019

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April 2022 Public Data File from Crossref

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Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/HeNCrj mice and human hepatoma-derived PLC/PRF/5 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pooling of animal experimental data reveals influence of study design and publication bias

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute hepatitis associated with the use of green tea infusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, semisynthesis, and evaluation of O-acyl derivatives of (-)-epigallocatechin-3-gallate as antitumor agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-phase synthesis of epigallocatechin gallate derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin gallate induces apoptosis in human hepatocellular carcinoma HepG2 cells via TGF/Smad signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma - United States, 2001-2006.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (−)-epigallocatechin-3-gallate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation kinetics of catechins in green tea powder: effects of temperature and relative humidity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols: implications for a cancer preventive mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea polyphenol epigallocatechin-3-gallate enhances 5-fluorouracil-induced cell growth inhibition of hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nanochemoprevention by encapsulation of (-)-epigallocatechin-3-gallate with bioactive peptides/chitosan nanoparticles for enhancement of its bioavailability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant and pro-oxidant activity of (-)-epigallocatechin-3-gallate in food emulsions: Influence of pH and phenolic concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylated-(3'')-epigallocatechin gallate analog suppresses tumor growth in Huh7 hepatoma cells via inhibition of angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the inhibition of the STAT3 signaling pathway by EGCG.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy inhibition contributes to the synergistic interaction between EGCG and doxorubicin to kill the hepatoma Hep3B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver transplantation for hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemopreventive and hepatoprotective effects of Epigallocatechin-gallate against hepatocellular carcinoma: role of heparan sulfate proteoglycans pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy-induced peripheral neuropathy: limitations in current prophylactic strategies and directions for future research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of gut microbiota and time of treatment on tissue levels of green tea polyphenols in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30858692

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2147/DDDT.S180079

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30858692%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30858692%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30858692%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

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