Wikidata

(Q7098997)

English

Optineurin

mammalian protein found in Homo sapiens

  • FIP-2
  • transcrption factor IIIA-interacting protein
  • huntingtin-interacting protein 7
  • OPTN
  • optic neuropathy-inducing protein
  • HIP-7
  • Huntingtin interacting protein L
  • nemo-related protein
  • TFIIIA-IntP
  • E3-14.7K-interacting protein
  • huntingtin yeast partner L
  • tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
  • transcription factor IIIA-interacting protein
  • optineurin
  • huntingtin-interacting protein L
In more languages

Statements

molecular function
protein binding
determination method
IPI
22 references
retrieved
8 April 2019
stated in
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection
GOA
curator
UniProt
UniProt protein ID
Q96CV9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
GOA
curator
UniProt
UniProt protein ID
Q96CV9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between optineurin and the bZIP transcription factor NRL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
The TBK1-binding domain of optineurin promotes type I interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Development and application of a DNA microarray-based yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Cargo binding induces dimerization of myosin VI.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Identification and comparative analysis of hepatitis C virus-host cell protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CV9
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE OPTN 202073 at fs.png
732 × 530; 12 KB
0 references

Identifiers

 
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