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Fyn can partially substitute for Lck in T lymphocyte development
scientific article published on 01 November 1996
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
title
Fyn can partially substitute for Lck in T lymphocyte development
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
author name string
T Groves
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
P Smiley
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
M P Cooke
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
K Forbush
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
R M Perlmutter
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
C J Guidos
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
publication date
1 November 1996
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
published in
Immunity
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
volume
5
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
page(s)
417-428
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
cites work
A signaling pathway governing early thymocyte maturation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation events during thymic selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine kinase triggering in thymocytes undergoing positive selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Syk tyrosine kinase required for mouse viability and B-cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive selection of CD4+ and CD8+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive selection of thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Receptors and signals in early thymic selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell development in mice lacking the CD3-zeta/eta gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Profound block in thymocyte development in mice lacking p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RAG-1-deficient mice have no mature B and T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role for ZAP-70 in both positive and negative selection of thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-cell development and selection in the intestinal epithelium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Participation of CD4 coreceptor molecules in T-cell repertoire selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction by lymphocyte antigen receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for Positive Selection of γδ Receptor-Bearing T Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental regulation of lck gene expression in T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-7613(00)80498-7
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
PubMed ID
8934569
1 reference
stated in
Europe PubMed Central
PubMed ID
8934569
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
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