(Q72494977)

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Studies on the reactivity of acyl glucuronides--VIII. Generation of an antiserum for the detection of diflunisal-modified proteins in diflunisal-dosed rats

scientific article published on 01 January 1995

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27 October 2019

Studies on the reactivity of acyl glucuronides--VIII. Generation of an antiserum for the detection of diflunisal-modified proteins in diflunisal-dosed rats (English)

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27 October 2019

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A M Williams

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27 October 2019

S Worrall

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27 October 2019

J De Jersey

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27 October 2019

R G Dickinson

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1 January 1995

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27 October 2019

Biochemical Pharmacology

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27 October 2019

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27 October 2019

209-217

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27 October 2019

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27 October 2019

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

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7 January 2021

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

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Studies of intramolecular rearrangements of acyl-linked glucuronides using salicylic acid, flufenamic acid, and (S)- and (R)-benoxaprofen and confirmation of isomerization in acyl-linked delta 9-11-carboxytetrahydrocannabinol glucuronide

1 reference

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Studies on the reactivity of acyl glucuronides--I. Phenolic glucuronidation of isomers of diflunisal acyl glucuronide in the rat

1 reference

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7 January 2021

Studies on the reactivity of acyl glucuronides--VII. Salicyl acyl glucuronide reactivity in vitro and covalent binding of salicylic acid to plasma protein of humans taking aspirin

1 reference

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7 January 2021

Studies on the reactivity of acyl glucuronides--II. Interaction of diflunisal acyl glucuronide and its isomers with human serum albumin in vitro

1 reference

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Irreversible binding of zomepirac to plasma protein in vitro and in vivo

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Studies on the reactivity of acyl glucuronides--VI. Modulation of reversible and covalent interaction of diflunisal acyl glucuronide and its isomers with human plasma protein in vitro

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Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism

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Drug-protein conjugation and its immunological consequences

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In vivo covalent binding of clofibric acid to human plasma proteins and rat liver proteins

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Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

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Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes

1 reference

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7 January 2021

Contrasting systemic stabilities of the acyl and phenolic glucuronides of diflunisal in the rat

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The sulphate conjugate of diflunisal: its synthesis and systemic stability in the rat

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Reactivity of diflunisal acyl glucuronide in human and rat plasma and albumin solutions

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7 January 2021

Studies on the reactivity of acyl glucuronides--IV. Covalent binding of diflunisal to tissues of the rat

1 reference

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7 January 2021

Studies on the reactivity of acyl glucuronides--V. Glucuronide-derived covalent binding of diflunisal to bladder tissue of rats and its modulation by urinary pH and beta-glucuronidase.

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Isolation of rat liver plasma membranes. Use of nucleotide pyrophosphatase and phosphodiesterase I as marker enzymes

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Detection of stable acetaldehyde-modified proteins in the livers of ethanol-fed rats

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Enzyme-linked immunoelectrotransfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis

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7 January 2021

Identifiers

10.1016/S0006-2952(94)00408-0

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7840798%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

1 reference

Europe PubMed Central

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27 October 2019

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