(Q73187743)

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Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

scientific article published on 01 November 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11077439%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11077439%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

3

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Europe PubMed Central

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2 November 2019

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C Méplan

1

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Europe PubMed Central

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2 November 2019

M J Richard

2

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Europe PubMed Central

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2 November 2019

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1 November 2000

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Europe PubMed Central

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2 November 2019

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11077439%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

19

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Europe PubMed Central

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2 November 2019

46

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Europe PubMed Central

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2 November 2019

5227-5236

1 reference

Europe PubMed Central

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2 November 2019

The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals

1 reference

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Measurement of intracellular free zinc in living neurons.

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Zinc metabolism in the brain: relevance to human neurodegenerative disorders

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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WAF1, a potential mediator of p53 tumor suppression

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Effect of p53 protein redox states on binding to supercoiled and linear DNA

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The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

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p53 and apoptosis

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Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

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Control of zinc transfer between thionein, metallothionein, and zinc proteins

1 reference

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The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1 reference

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Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector

1 reference

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A plant metallothionein produced in E. coli.

1 reference

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Inhibitory sites in enzymes: zinc removal and reactivation by thionein

1 reference

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Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells

1 reference

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Redox signalling and transition metals in the control of the p53 pathway

1 reference

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Flexibility: the key to p53 function?

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Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

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Cell cycle regulation of metallothionein in human colonic cancer cells

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

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7 January 2021

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Metal chelator NNNNN-tetrakis-(2-pyridymethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes

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Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine.

1 reference

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Kinetics of zinc uptake and exchange by primary cultures of rat hepatocytes

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The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

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A model for p53-induced apoptosis

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Role of cysteine residues in regulation of p53 function

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Regulatory role of metallothionein in NF-kappaB activation

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Transient peaks in zinc and metallothionein levels during differentiation of 3T3L1 cells

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Transition metals modulate DNA-protein interactions of SP1 zinc finger domains with its cognate target site

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Thioredoxin-dependent redox regulation of p53-mediated p21 activation

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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GADD45 induction of a G2/M cell cycle checkpoint

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Involvement of metallothionein and copper in cell proliferation

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

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Changes in distribution of labile zinc in mouse spermatozoa during maturation in the epididymis assessed by the fluorophore Zinquin

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Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1.

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Zinc transfer from transcription factor IIIA fingers to thionein clusters

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