(Q73618027)

English

Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cell

scientific article published on 01 August 1997

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scholarly article

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5 November 2019

Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cells. Identification of a new Grb2.Sos1 binding site (English)

1 reference

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5 November 2019

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D Thomas

1

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5 November 2019

R A Bradshaw

2

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1 August 1997

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5 November 2019

Journal of Biological Chemistry

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5 November 2019

272

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5 November 2019

22293-22299

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5 November 2019

35

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5 November 2019

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Signal transduction. How receptors turn Ras on.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

SH2/SH3 signaling proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

The PTB domain: a new protein module implicated in signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Binding of Shc to the NPXY motif is mediated by its N-terminal domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Characterization and isolation of proteolytically modified nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Production of high-titer helper-free retroviruses by transient transfection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.22293

21 January 2018

Identifiers

10.1074/JBC.272.35.22293

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9268379%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9268379%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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